PMID: 9429130Jan 16, 1998Paper

Behavioral and cognitive effects of lamotrigine

Journal of Child Neurology
K J Meador, G A Baker

Abstract

Lamotrigine is a new antiepileptic drug that may possess unique cognitive and behavioral characteristics. Although lamotrigine can produce neurobehavioral toxicity, it is generally well tolerated. In one study directly comparing lamotrigine to placebo as add-on therapy in patients with intractable epilepsy, no objective cognitive effects were observed in a limited neuropsychological battery. Several studies have demonstrated favorable effects of lamotrigine on psychological well-being that were not explained by simple effects on seizure frequency and severity. In direct comparisons with carbamazepine and phenytoin, lamotrigine has been reported to produce positive effects on quality of life scales of patient perception. In addition, positive behavioral effects have also been observed in two blinded studies and several open trials for patients with severe mental disability and refractory epilepsy. Future studies with more extensive neuropsychological assessments are needed to delineate the differential cognitive and behavioral effects of lamotrigine in epilepsy and psychiatric disorders.

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Citations

Oct 19, 2007·Neuropsychology Review·David W LoringKimford J Meador
Mar 1, 2003·Epilepsy & Behavior : E&B·Laura S. BoylanTerence A. Ketter
Jun 26, 2001·Epilepsia·A P Aldenkamp
Sep 27, 2003·Epilepsia·Rocio Sánchez-Carpintero, Brian G R Neville
Sep 22, 2005·Epilepsy Currents·Siddhartha Nadkarni, Orrin Devinsky
Mar 22, 2014·Journal of Epilepsy Research·Sung Min KimKi-Young Jung
Sep 16, 1999·Epilepsia·K J MeadorW T Goff
Aug 28, 2010·Brain & Development·Minseon YunSun Jun Kim
Mar 6, 2003·Neurologic Clinics·Ann M Bergin, Mary Connolly
Mar 12, 2002·Acta Neurologica Scandinavica·Ph GelisseM Baldy-Moulinier
Mar 3, 2010·CNS Drugs·Dean P Sarco, Blaise F D Bourgeois
Mar 24, 2018·Future Science OA·Kathleen F Holton, Elizabeth W Cotter
Aug 12, 2006·Journal of Child Neurology·Jerry R McKeeAnn E Hammer
Apr 30, 2002·The Annals of Pharmacotherapy·Stephen C Hurley
Jul 28, 2020·Current Pharmaceutical Design·Kate LevenbergDaniel R George

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