Behavioral and cognitive impact of early life stress: Insights from an animal model

Progress in Neuro-psychopharmacology & Biological Psychiatry
Hesong LiuSamina Salim

Abstract

Children subjected to traumatic events during childhood are reported to exhibit behavioral and cognitive deficits later in life, often leading to post-traumatic stress disorder (PTSD) and major depression. Interestingly, some children continue to remain normal despite being exposed to the same risk factors. These trauma-related behavioral and cognitive profiles across different stages of life are not well understood. Animal studies can offer useful insights. The goal of this study was to determine the impact of early life exposure to traumatic events on behavioral and cognitive profile in rats by tracking the behavior of each rat at different ages. We utilized the single prolonged stress (SPS), a rodent model of PTSD, to study the effects of early life stress. Male Sprague-Dawley rats were exposed to SPS on post-natal day (PND) 25. Tests to assess anxiety- and depression-like behavior, as well as learning and memory function were performed at PND32, 60 and 90. Rats exposed to SPS exhibited both anxiety- and depression-like behavior at PND32. And, short-term (STM) but not long-term memory (LTM) was impaired. Rats exposed to SPS at PND60 exhibited anxiety- but not depression-like behavior. STM but not LTM was impaired. Rats expos...Continue Reading

References

Feb 23, 2010·Developmental Psychobiology·David M LyonsAlan F Schatzberg

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Citations

Mar 5, 2019·Behavioural Pharmacology·Karem H AlzoubiMahmoud A Alfaqih
Jan 8, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Saulo G TractenbergRodrigo Grassi-Oliveira
Nov 13, 2019·Behavioural Brain Research·Karem H AlzoubiMahmoud A Alfaqih
Mar 13, 2021·Environmental Toxicology and Pharmacology·Nour-Eddine KaikaiMohamed Bennis
Oct 28, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Hesong LiuSamina Salim
May 19, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ai-Shan SuJing Zou

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