Behavioral and electromyographic characterization of mice lacking EphA4 receptors

Journal of Neurophysiology
Turgay AkayKeir Pearson

Abstract

EphA4 receptors play an important role in axon guidance during development. Disrupting the expression of these receptors in mice has been shown to modify neuronal connections in the spinal cord and results in the production of a characteristic hopping gait. The EphA4-null mouse has been used in numerous investigations aimed at establishing mechanisms responsible for patterning motor activity during walking. However, there have been no detailed behavioral or electrophysiological studies on adult EphA4-null mice. We used high-speed video recordings to determine the coordination of leg movements during locomotion in adult EphA4-null mice. Our data show that the hopping movements of the hind legs are not always associated with synchronous movements of forelegs. The coupling between the forelegs is weak, resulting in changes in their phase relationship from step to step. The synchronous coordination of the hind legs can switch to an alternating pattern for a short period of time during recovery from isoflurane anesthesia. Comparison of the kinematics of hind leg movements in EphA4-null mice and wild-type animals shows that besides the synchronous coordination in EphA4-null mice, the swing durations and the swing amplitude are shorte...Continue Reading

References

Jan 1, 1987·Experimental Brain Research·P A FortierS Rossignol
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·M DottoriA W Boyd
Feb 3, 1999·Annals of the New York Academy of Sciences·A BonnotD Viala
Jul 15, 1999·Physiology & Behavior·K A Clarke, J Still
Jan 5, 2000·Physiological Reviews·J DuysensH Cruse
Nov 21, 2000·Current Opinion in Neurobiology·T M Jessell, J R Sanes
Dec 9, 2000·Journal of Neurophysiology·P WhelanM J O'Donovan
Mar 10, 2001·Nature·P A LeightonM Tessier-Lavigne
Jun 8, 2002·Annual Review of Neuroscience·Ryuichi Shirasaki, Samuel L Pfaff
Oct 9, 2002·Current Opinion in Neurobiology·Martyn GouldingSujatha Narayan
Feb 19, 2003·Brain Research. Brain Research Reviews·Agnès BonnotMichael J O'Donovan
Feb 10, 2004·Neuron·Ole Kiehn, Klas Kullander
Nov 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yona GoldshmitAnn M Turnley
Feb 22, 2005·Current Opinion in Neurobiology·Martyn Goulding, Samuel L Pfaff
May 24, 2005·Journal of Neuroscience Methods·K G PearsonK Fouad
Jul 30, 2005·Experimental Neurology·Michelle L StarkeyElizabeth J Bradbury
Aug 2, 2005·Journal of Neuroscience Methods·Hans Christoph ScholleNikolaus Peter Schumann
Sep 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Simon J B ButtOle Kiehn
Mar 10, 2006·Nature·Simon GosgnachMartyn Goulding
Apr 28, 2006·Journal of Neurophysiology·Turgay AkayKeir G Pearson

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Citations

Oct 19, 2012·PloS One·Eri TakeuchiDai Yanagihara
Mar 22, 2013·PloS One·Georgette L SuidanDenisa D Wagner
Feb 2, 2013·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Vicki M TysselingMatthew C Tresch
Nov 26, 2008·Physiology & Behavior·Christine M WooleyKevin L Seburn
Oct 12, 2007·Brain Research Reviews·Larry M JordanKeir G Pearson
Jul 23, 2015·BMC Biology·César S MendesRichard S Mann
Aug 3, 2010·Journal of Biomechanics·Jitendra PrasadTed S Gross
Sep 27, 2014·Journal of Neuro-oncology·Nicole McKinneyTobey J MacDonald
Nov 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Turgay AkayThomas M Jessell
Apr 21, 2017·Genes, Brain, and Behavior·S KiesslingV Mongrain
May 20, 2018·The Journal of Experimental Biology·William Paganini Mayer, Turgay Akay
Oct 12, 2018·Journal of Neurophysiology·Olivier D Laflamme, Turgay Akay
Feb 7, 2019·Behavior Genetics·Oleg N Tikhodeyev, Оlga V Shcherbakova
Mar 28, 2019·The Journal of Physiology·Alessandro SantuzAdamantios Arampatzis
Apr 28, 2006·Journal of Neurophysiology·Turgay AkayKeir G Pearson
Aug 21, 2020·Journal of Neurophysiology·Alessandro Santuz, Turgay Akay
Jun 14, 2017·Scientific Reports·Lauren BroomVeronique G VanderHorst
Sep 1, 2017·Journal of Neurophysiology·Lea Ziskind-Conhaim, Shawn Hochman
Apr 8, 2020·Journal of Neuroscience Methods·Samantha CermakHanbing Lu
Aug 20, 2021·Frontiers in Aging Neuroscience·Lauren BroomVeronique G VanderHorst

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