Behavioral and electrophysiological consequences of deafferentation following chronic constriction of the infraorbital nerve in adult rats

Archives of Oral Biology
E H Chudler, Leigh C Anderson

Abstract

Deafferentation of the hind paw following sciatic nerve injury results in behavioral changes, such as autotomy, suggestive of persistent, spontaneous pain. The effects of deafferentation involving trigeminal nerves have, however, received less attention. Here, alterations in trigeminal ganglion neuronal activity and mechanically evoked and spontaneous behavior were studied in adult rats after a chronic constriction injury of the infraorbital nerve (ION). Compared to sham-operated rats, most rats with ION damage were unresponsive to mechanical stimulation of the mystacial vibrissae up to 56 days after surgery. Increased facial grooming was observed only in rats with chronic ION constriction 10 days after surgery. Free-ranging behavior was similar to that of sham-injury animals. In contrast, increases in the number of spontaneously active trigeminal ganglion neurones were observed in those rats with ION injuries at both 3 and 56 days. These data suggest that chronic constrictive injuries of the ION resulting in prolonged loss of low-threshold input from the periphery lead to only transient behavioral changes, despite the presence of spontaneous activity in trigeminal sensory neurones.

References

Oct 1, 1993·Muscle & Nerve·G J Bennett
Oct 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·D J Tracey, J S Walker
Aug 1, 1997·Experimental Brain Research·Y ImamuraO Nakanishi

❮ Previous
Next ❯

Citations

Aug 19, 2008·The Journal of Pain : Official Journal of the American Pain Society·Mei XuCharles Chavkin
Mar 18, 2006·European Journal of Pain : EJP·James E BiggsPeter P Robinson
May 17, 2012·Journal of Neuroscience Research·Átila SaverniniMaria Salete Abreu de Castro
Oct 21, 2004·Brain Research·Shelley L DaviesFiona M Boissonade
Sep 9, 2008·European Journal of Pain : EJP·Dong K AhnYong C Bae
Mar 28, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Hye J JeonDong K Ahn
Mar 3, 2005·Archives of Oral Biology·Eric H Chudler, Margaret R Byers
Mar 12, 2011·Journal of Dental Research·A NakajimaK Iwata
Sep 18, 2018·Expert Opinion on Drug Discovery·Heitor G Araújo-FilhoJullyana S S Quintans

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.