Behavioral and growth effects induced by low dose methamphetamine administration during the neonatal period in rats

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Michael T WilliamsCharles V Vorhees

Abstract

The investigation of methamphetamine exposure during neonatal development in rats has demonstrated that long-term spatial learning deficits are induced. A previous dose-response study showed that administration of 5 mg/kg methamphetamine, four times daily from postnatal days 11 to 20 produced these deficits, although the effects were not as severe as at higher doses of 10 or 15 mg/kg. This study examined concentrations of methamphetamine at or below 5mg/kg given over the same period of time. Five different concentrations of methamphetamine (i.e., 5, 2.5, 1.25, 0.625, or 0) were administered every 2 h four times daily from postnatal days 11 to 20. Body weights, zero maze performance, and Morris water maze learning were examined. A dose-dependent decrease in body weight was observed during the period of methamphetamine administration and these lower weights continued throughout adulthood for the 5, 2.5, and 1.25 mg/kg concentrations, although the adult decreases were negligible. No differences were noted in the zero maze. In the Morris water maze during the acquisition period, dose-dependent differences in spatial orientation were seen, however non-dose related deficits were observed for other parameters. During the shifted platf...Continue Reading

References

May 1, 1976·The Journal of Nutrition·R S Redman, L R Sweney
Apr 1, 1992·Journal of Developmental and Behavioral Pediatrics : JDBP·J M Struthers, R L Hansen
Apr 17, 1991·JAMA : the Journal of the American Medical Association·D J BurchfieldC L DeVane
Jul 1, 1990·Home Healthcare Nurse·J Caserta
Jul 1, 1988·Neurotoxicology and Teratology·T A Fico, C Vanderwende
Oct 1, 1987·The Journal of Pediatrics·A S Oro, S D Dixon
Oct 3, 1980·Science·E M Blass, M H Teicher
Aug 1, 1995·The Journal of Nutrition·D A Levitsky, B J Strupp
Aug 1, 1995·The Journal of Nutrition·B J Strupp, D A Levitsky
Sep 1, 1993·Developmental Medicine and Child Neurology·R L HansenS M Gospe
Jan 8, 2000·Physiology & Behavior·R L Roof, D G Stein
Dec 7, 2000·Neurotoxicology and Teratology·M T WilliamsC V Vorhees
Jul 12, 2002·Behavioural Brain Research·Marisa Tomoe Hebihara FukudaSebastião Sousa Almeida
Aug 24, 2002·The European Journal of Neuroscience·L L MorfordC V Vorhees
Feb 14, 2003·Journal of Developmental and Behavioral Pediatrics : JDBP·Lynne SmithCarol Berkowitz
Apr 10, 2003·Psychopharmacology·Michael T WilliamsCharles V Vorhees
Jun 5, 2003·Physiology & Behavior·Elisabetta BaldiBucherelli Corrado
Jul 19, 2003·Pharmacological Reviews·A Richard GreenM Isabel Colado
Aug 10, 1990·Science·A K Cho

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Citations

Apr 5, 2007·Nature Protocols·Charles V Vorhees, Michael T Williams
Aug 6, 2011·American Journal of Perinatology·Rachel ZabanehBarry M Lester
Sep 1, 2007·Behavioural Pharmacology·Charles V VorheesMichael T Williams
Mar 29, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Kate McDonnell-DowlingJohn P Kelly
Sep 17, 2014·ILAR Journal·Charles V Vorhees, Michael T Williams
Jan 13, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Charles V VorheesMichael T Williams
May 27, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Charles V VorheesMichael T Williams
Aug 15, 2013·Prevention Science : the Official Journal of the Society for Prevention Research·Beau AbarBarry M Lester
Sep 13, 2005·Pediatric Clinics of North America·Julian K Davies, Julia M Bledsoe
Jul 5, 2005·Free Radical Biology & Medicine·Winnie JengPeter G Wells
Jun 15, 2016·Birth Defects Research. Part C, Embryo Today : Reviews·Sarah A JablonskiCharles V Vorhees
Nov 7, 2016·Neurotoxicity Research·Sarah A JablonskiMichael T Williams
Jun 6, 2009·Nature Reviews. Gastroenterology & Hepatology·Minoti V ApteJeremy S Wilson
May 20, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Summer F AcevedoJacob Raber
Oct 25, 2006·Stress : the International Journal on the Biology of Stress·Michael T WilliamsCharles V Vorhees
Feb 12, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Michael T WilliamsCharles V Vorhees
Oct 9, 2007·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M DostalekA Sulcova
Nov 5, 2020·Brain Sciences·Nataliya A KrupinaNadezhda N Khlebnikova

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