Behavioral and neuroanatomical approaches in models of neurodevelopmental disorders: opportunities for translation

Current Opinion in Neurology
Jill L Silverman, Jacob Ellegood

Abstract

This review highlights the invaluable contribution of in-vivo rodent models in dissecting the underlying neurobiology for numerous neurodevelopmental disorders. Currently, models are routinely generated with precision genomics and characterized for research on neurodevelopmental disorders. In order to impact translation, outcome measures that are translationally relevant are essential. This review emphasizes the importance of accurate neurobehavioral and anatomical analyses. Numerous well validated assays for testing alterations across behavioral domains with sensitivity and throughput have become important tools for studying the effects of genetic mutations on neurodevelopment. Recent work has highlighted relationships and links between behavioral outcomes and various anatomical metrics from neuroimaging via magnetic resonance. These readouts are biological markers and outcome measures for translational research and will be have important roles for genetic or pharmacologic intervention strategies. Combinatorial approaches that leverage translationally relevant behavior and neuroanatomy can be used to develop a platform for assessment of cutting edge preclinical models. Reliable, robust behavioral phenotypes in preclinical mode...Continue Reading

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Citations

Sep 29, 2019·Scientific Reports·Robert J ThornRobbert Creton
Oct 20, 2018·Frontiers in Integrative Neuroscience·Olga I Dadalko, Brittany G Travers
Sep 4, 2020·Journal of Neurochemistry·Thomas J TurnerGabriele Lignani
Dec 4, 2020·Neural Regeneration Research·Marika PremoliSara Anna Bonini

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