Behavioral and neuroanatomical outcomes in a rat model of preterm hypoxic-ischemic brain Injury: Effects of caffeine and hypothermia

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Molly PotterR Holly Fitch

Abstract

The current study investigated behavioral and post mortem neuroanatomical outcomes in Wistar rats with a neonatal hypoxic-ischemic (HI) brain injury induced on postnatal day 6 (P6; Rice-Vannucci HI method; Rice et al., 1981). This preparation models brain injury seen in premature infants (gestational age (GA) 32-35 weeks) based on shared neurodevelopmental markers at time of insult, coupled with similar neuropathologic sequelae (Rice et al., 1981; Workman et al., 2013). Clinically, HI insult during this window is associated with poor outcomes that include attention deficit hyperactivity disorder (ADHD), motor coordination deficits, spatial memory deficits, and language/learning disabilities. To assess therapies that might offer translational potential for improved outcomes, we used a P6 HI rat model to measure the behavioral and neuroanatomical effects of two prospective preterm neuroprotective treatments - hypothermia and caffeine. Hypothermia (aka "cooling") is an approved and moderately efficacious intervention therapy for fullterm infants with perinatal hypoxic-ischemic (HI) injury, but is not currently approved for preterm use. Caffeine is a respiratory stimulant used during removal of infants from ventilation but has show...Continue Reading

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Citations

Dec 31, 2020·International Journal of Molecular Sciences·Katarzyna SocałaPiotr Wlaź
Mar 18, 2021·Cellular and Molecular Neurobiology·D Pereira-FigueiredoK C Calaza
Mar 14, 2021·Experimental Neurology·Victor Daniel Vasquez MatsudaSilvia Honda Takada
Aug 13, 2021·Stem Cell Reviews and Reports·Catherine BrégèreRaphael Guzman
Oct 7, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Maria L DiasFiona B McDonald

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