Behavioral and neurochemical consequences of perinatal exposure to lead in adult male Wistar rats: protective effect by Centella asiatica

Environmental Science and Pollution Research International
Swetha ChintapantiP Sreenivasula Reddy

Abstract

The present study evaluated the protective effects of Centella asiatica (CA) leaf extract on behavioral deficits and neurotoxicity in adult rat exposed to lead during perinatal period. Adult Wistar rats were exposed to 0.15% lead acetate (Pb) from gestation day 6 through drinking water and the pups were exposed lactationally to Pb till weaning. Significant perturbations in locomotor activity and exploratory behavior were observed in rats exposed to Pb during perinatal period. The levels of lipid peroxidation increased significantly with a reduction in levels of glutathione and activity levels of acetylcholinesterase and antioxidant enzymes in hippocampus, cerebrum, cerebellum, and medulla of brains excised from Pb-exposed rats. Oral supplementation of CA during postweaning period provided significant protection against Pb-induced behavioral impairments and neurotoxicity, without chelating tissue Pb levels. The possible neuroprotective efficacy of CA may be due to its antioxidant potential but not by lowering effects of brain Pb content.

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Aug 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M Hermes-LimaE J Bechara
Jan 1, 1990·Basic Life Sciences·D M Nicholls, D R McLachlan
Jan 1, 1985·Methods in Enzymology·I Carlberg, B Mannervik
Nov 15, 1974·Brain Research·E J FjerdingstadE Fjerdingstad
May 1, 1984·Journal of Neuroscience Methods·R Morris
Jan 1, 1984·Methods in Enzymology·L Flohé, W A Günzler
Mar 1, 1994·International Journal of Cardiology·K K TalwarH S Wasir
Sep 30, 1993·Behavioural Brain Research·E F Espejo, D Mir
Sep 1, 1996·Pharmacology & Toxicology·A L RodriguesD O Souza
Jun 1, 1999·Journal of Ethnopharmacology·A ShuklaB N Dhawan
Jun 6, 2000·Pharmacology, Biochemistry, and Behavior·S E FileS Cheeta
Nov 17, 2001·Neurotoxicology and Teratology·E G MoreiraV S Vassilieff
Jan 22, 2002·Journal of Ethnopharmacology·M H Veerendra Kumar, Y K Gupta
Aug 20, 2002·Archives of Toxicology·Rajagopalan SivaprasadPalaninathan Varalakshmi
Dec 13, 2002·Brain : a Journal of Neurology·Theodore I Lidsky, Jay S Schneider
Feb 27, 2003·Toxicology·M Luisa LeretM Teresa Antonio
Jul 16, 2003·Clinical and Experimental Pharmacology & Physiology·M H Veerendra Kumar, Y K Gupta
Aug 21, 2003·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Gottipuolu R ReddyChellu S Chetty
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Oct 24, 2003·Carbohydrate Research·Xue-Song WangJi-Nian Fang
Feb 21, 2006·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·P WijeweeraZ Merali
Jan 17, 2008·Neuroscience and Behavioral Physiology·B Ya RyzhavskiiS N Baranova
Apr 22, 2009·Journal of Neuroscience Research·Rajanikant G KrishnamurthyArshad Majid
Nov 20, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jacinda T James, Ian A Dubery
Dec 29, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R P Jaya PrasanthiG Rajarami Reddy
Mar 16, 2011·Toxicology Letters·Patrícia ReckziegelMarilise Escobar Bürger
Jul 27, 2011·Environmental Toxicology and Pharmacology·Yaping JinJun Yang
Feb 14, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D Chand BashaG Rajarami Reddy
Jun 6, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Ilkay Erdogan Orhan
Jan 23, 2015·BioMed Research International·Kota V RamanaAramati B Reddy

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Citations

Dec 5, 2018·Toxicology Research·A K Sai Siva RamP Sreenivasula Reddy
Oct 6, 2020·Frontiers in Pharmacology·Boju SunTonghua Liu
Mar 27, 2020·Human & Experimental Toxicology·R S BatyR B Kassab
Feb 3, 2021·Toxics·Daniela Ramírez OrtegaVerónica Pérez de la Cruz

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