PMID: 1208759Nov 21, 1975Paper

Behavioral and neuropharmacological analysis of amphetamine and 2,5-dimethoxy-4-methylamphetamine in rats

Psychopharmacologia
H A TilsonJ H Chamberlain

Abstract

A comparison of the behavioral pharmacology of DOM and amphetamine in rats indicated that lower doses (0.10-1.0 mg/kg) of the two agents had similar effects on schedule-controlled food-reinforced and shock-avoidance behavior. Similarities were also noted in their effects on horizontally directed motor activity when testing was preceeded by a period of acclimation. However, most doses of DOM tended to decrease unacclimated motor activity, while amphetamine increased this behavior. Neuropharmacological antagonism studies indicated that brain catecholamines (CA) and serotonin (5-HT) are involved in the behavioral effects of both DOM and amphetamine. Cinanserin, a 5-HT receptor blocker, attenuated the behavioral disruptive effects of both agents on food-reinforced responding. Cinanserin attenuated the effects of all doses of DOM and those of higher doses of amphetamine on shock avoidance. When given prior to lower doses of amphetamine, there was a greater behavioral stimulation than when amphetamine was given alone. Prior depletion of brain CA with alpha-methyltyrosine (alpha-MT) did not affect DOM induced disruption of food-reinforced responding, while alpha-MT attenuated the behavioral effects of all doses of DOM and amphetamine ...Continue Reading

References

Dec 1, 1972·Journal of Comparative and Physiological Psychology·A K Swonger, R H Rech
Sep 1, 1968·The American Journal of Psychiatry·S H SnyderH Weingartner
Apr 11, 1973·Nature: New Biology·F BeningtonR J Bradley
Jan 1, 1973·Journal of the Experimental Analysis of Behavior·D E McMillan
Sep 20, 1968·Psychopharmacologia·J B Appel, D X Freedman
Jan 1, 1969·The British Journal of Psychiatry : the Journal of Mental Science·J R SmythiesR J Bradley
Jan 1, 1966·Psychopharmacologia·C R SchusterJ H Woods
Oct 1, 1962·Journal of the Experimental Analysis of Behavior·J ZIMMERMAN, C R SCHUSTER

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Citations

May 15, 1977·European Journal of Pharmacology·H A TilsonJ P Buyniski
Dec 17, 1981·European Journal of Pharmacology·R A GlennonR Young
Jan 2, 1989·European Journal of Pharmacology·J B Appel, P M Callahan
Mar 1, 1981·Pharmacology, Biochemistry, and Behavior·R A GlennonR Young
May 1, 1985·Pharmacology, Biochemistry, and Behavior·J W HenckR H Rech
Jan 1, 1985·Progress in Neuro-psychopharmacology & Biological Psychiatry·L M Adams, M A Geyer
Dec 23, 1976·Radiation and Environmental Biophysics·W Lohmann
Dec 19, 2020·Neurotoxicity Research·Adam WojtasKrystyna Gołembiowska

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