Behavioral and pharmacological studies on the validation of a new animal model for attention deficit hyperactivity disorder

Neurobiology of Learning and Memory
T PuumalaJ Sirviö

Abstract

Childhood hyperactivity (attention deficit hyperactivity disorder, ADHD) is a common behavior disorder among grade-school children. The characteristic symptoms are attentional problems and hyperkinesia. A number of animal models for ADHD syndrome have been developed, but very few of these models are truly representative in that they rarely describe both hyperactivity and attentional problems. Frequently the disorder has been induced in animals by pharmacological manipulations or exogenous brain lesions which are distinct from the disturbances in normal developmental processes which ultimately lead to ADHD. The main purpose of the present research was to develop a new animal model of ADHD, such that it would include an attention deficit, hyperactivity and alleviation by treatment with a psychostimulant. We used rats trained for a 5-choice serial reaction time task which assessed sustained attention. In this behavioral paradigm, rats are required to discriminate spatially a short visual stimulus that will occur randomly in one of five locations and have to maintain an adequate activity level. The ability of a rat to maintain its attention on the task can be measured by counting choice accuracy (percent correct responses), whereas...Continue Reading

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