Behavioral and Serotonergic Changes in the Frontal Cortex Following Methamphetamine Self-Administration.

The International Journal of Neuropsychopharmacology
Lisa M McFaddenAndrew Johansen

Abstract

Methamphetamine use is associated with a variety of negative health outcomes, including psychosis. The frontal cortex serotonin receptors are thought to contribute to psychosis-like behaviors. This study investigated changes in serotonergic markers in the frontal cortex following methamphetamine self-administration and hallucinogenic drug-induced behavior. Consistent with previously published studies, freely cycling male and female rats were allowed to self-administer methamphetamine (males: 0.12 mg/infusion; females: 0.09 mg/infusion) or saline (10 µL) for 7 days. On the day following self-administration or following 10 days of extinction training, animals were given the serotonin 2A/2C agonist, 1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (2 mg/kg, i.p.), and head twitches were analyzed. Autoradiography was also used to assess serotonin receptors and transporters in the frontal cortex following self-administration. Methamphetamine self-administration led to an increase in DOI-induced head-twitch behavior compared to saline only on the day following self-administration. Increases in serotonin receptors in the orbitofrontal cortex and decreases in serotonin transporters in the orbitofrontal cortex and infralimbic...Continue Reading

References

Feb 5, 1999·Naunyn-Schmiedeberg's Archives of Pharmacology·D L NelsonR A Glennon
Aug 6, 2003·The American Journal of Psychiatry·Akira KugayaRobert B Innis
Jul 20, 2010·Drug and Alcohol Review·Rebecca McKetinKerri Lawrence
Sep 16, 2010·Addiction·Todd ZorickEdythe D London
Sep 23, 2010·The Journal of Pharmacology and Experimental Therapeutics·W E FantegrossiJ H Woods
Feb 23, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nina Bl UrbanMarc Laruelle
Aug 15, 2013·The International Journal of Neuropsychopharmacology·Adam L Halberstadt, Mark A Geyer
Apr 29, 2014·Behavioural Brain Research·Christian P Müller, Judith R Homberg
Aug 8, 2014·Frontiers in Human Neuroscience·Jennifer H HsiehFleur M Howells
Oct 2, 2014·The Journal of Pharmacology and Experimental Therapeutics·Douglas A SmithWilliam E Fantegrossi
Nov 7, 2014·CNS Drugs·Suzette Glasner-Edwards, Larissa J Mooney
Dec 9, 2016·Proceedings of the National Academy of Sciences of the United States of America·Nathaniel E ClarkP John Hart
Apr 5, 2017·The Annals of Pharmacotherapy·Kevin M BozymskiEricka L Crouse
Jun 24, 2017·Drug and Alcohol Dependence·Andrew Johansen, Lisa M McFadden

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.