Behavioral, biochemical and cellular correlates in the protective effect of sertraline against transient global ischemia induced behavioral despair: possible involvement of nitric oxide-cyclic guanosine monophosphate study pathway

Brain Research Bulletin
Vaibhav Gaur, Anil Kumar

Abstract

Post-stroke depression (PSD) is one of the psychiatric complications after stroke. Present study was conducted to elucidate the protective effect of sertraline and possible involvement of nitric oxide mechanism against transient global ischemia induced behavioral despair. Bilateral common carotid artery occlusion was given twice for 5 min at 10 min interval followed by 96 h reperfusion. Ischemia reperfusion significantly increased immobility period and decreased resistance to lateral push as compared to sham-operated group. Ischemia reperfusion caused significant oxidative damage and mitochondrial enzyme complex (I-III) dysfunction as compared to sham group. Sertraline (5 and 10mg/kg) treatment significantly reduced immobility period, increased resistance to lateral push, attenuated oxidative damage and restored mitochondrial enzyme complex activities as compared to ischemia group. L-Arginine (100mg/kg) or sildenafil (5mg/kg) pretreatment with sertraline (5mg/kg) significantly reversed the protective effect of sertraline. However, L-NAME (10mg/kg) or 7NI (10mg/kg) pretreatment with sertraline (5mg/kg) significantly potentiated their protective effect which were significant as compared to their effect alone. The present study sh...Continue Reading

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Citations

Jul 30, 2014·PloS One·Ritesh K BabootaMahendra Bishnoi
Feb 24, 2016·Brain Research Bulletin·Anil KumarVarun Gupta
Jan 30, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yi-Tao HeYi Guo
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Feb 22, 2012·Journal of Cellular and Molecular Medicine·Isabelle LoubinouxAurel Popa-Wagner
Jul 12, 2011·Physiology & Behavior·Adriana PedreañezJesús Mosquera
Jul 28, 2016·Frontiers in Neuroendocrinology·P Barra de la Tremblaye, H Plamondon
Jul 27, 2018·Journal of Biomolecular Structure & Dynamics·Naresh KumarNidhi Goel
Jul 20, 2019·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·L HolperJ J Mann
Mar 17, 2020·European Journal of Pharmacology·Akbar Hajizadeh MoghaddamVahid Hasantabar

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