Behavioral characteristics of a nervous system-specific erbB4 knock-out mouse

Behavioural Brain Research
Mari S GolubK C Kent Lloyd

Abstract

ErbB4 is an important brain receptor for the neuregulin1 growth factor. A conditional knock-out mouse was developed lacking both alleles of the erbB4 gene in neurons/glia, and one allele in other cells. The conditional mutant mice were compared to heterozygous null (one null allele and one wildtype allele in all tissues) and wildtype control (no gene deletion) littermates in a battery of behavioral tests. Conditional mutants displayed a lower level of spontaneous motor activity and reduced grip strength compared to wildtype control mice. Group mean scores of heterozygous nulls were intermediate on these measures. However, heterozygous nulls were delayed in motor development and male heterozygous nulls demonstrated altered cue use in a Morris maze learning and memory task relative to both wildtype control and conditional mutant mice. These findings were interpreted based on more detailed analysis of the behavioral data and considerations of the complex nature and multiple roles of the neuregulin/erbB4 system in the nervous system.

References

Feb 1, 1994·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J S Tegeris, R L Balster
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A NagyJ C Roder
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·G D PlowmanM Shoyab
Nov 24, 1999·Neurotoxicology and Teratology·C L Kwik-UribeC L Keen
Apr 6, 2000·The Journal of Endocrinology·M R KritzikN Sarvetnick
May 29, 2000·Journal of Molecular Evolution·R A Stein, J V Staros
Jun 27, 2000·The Journal of Biological Chemistry·C SweeneyK L Carraway
Sep 21, 2000·Toxicology·M S GolubC L Keen
Dec 14, 2001·The Journal of Biological Chemistry·Hahn-Jun LeeTae-Wan Kim
Jul 12, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·K FriedC Lillesaar
Jul 18, 2002·Endocrine-related Cancer·M Harries, I Smith

❮ Previous
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Citations

Oct 16, 2008·European Journal of Human Genetics : EJHG·Liesbeth BackxHilde Van Esch
Oct 5, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Robert E McCullumsmithJames H Meador-Woodruff
May 15, 2008·Nature Reviews. Neuroscience·Lin Mei, Wen-Cheng Xiong
Nov 30, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·William T Carpenter, James I Koenig
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Lei WenLin Mei
Feb 22, 2012·Human Molecular Genetics·Rima WoodsJanine M LaSalle
Nov 13, 2004·Neuroreport·Olli KampmanTerho Lehtimäki
Jun 7, 2011·Alzheimer Disease and Associated Disorders·Diana RibesJosé L Domingo
Jun 1, 2006·Genes, Brain, and Behavior·P J JaubertR F Berman
Feb 15, 2011·American Journal of Respiratory Cell and Molecular Biology·Katja ZscheppangChristiane E L Dammann
Mar 2, 2006·Cell Structure and Function·Ryo Iwamoto, Eisuke Mekada
Mar 2, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alon ShamirAndres Buonanno
Aug 12, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jianhua Chu, Stewart A Anderson
May 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kristine RoyGabriel Corfas
Feb 25, 2014·Pharmacology & Therapeutics·Catherine L WinchesterBrian J Morris
Nov 6, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Robert F BermanJean Harry
Nov 21, 2014·Journal of Pharmacological Sciences·Yoshiaki Miyamoto, Atsumi Nitta
Dec 4, 2012·Neurobiology of Disease·Melis InanStewart A Anderson
Oct 2, 2012·Neurotoxicology and Teratology·Claire M KoenigRobert F Berman
Jan 9, 2016·Neuroscience and Biobehavioral Reviews·Rachel Anne Hill
Aug 6, 2011·Neurotoxicology and Teratology·Judith I HillsCarl L Keen
Jan 7, 2016·Frontiers in Cellular Neuroscience·Carlos G Perez-Garcia
Feb 8, 2011·Current Opinion in Genetics & Development·Beatriz Rico, Oscar Marín
Oct 30, 2015·Progress in Neurobiology·Yavuz AyhanMikhail V Pletnikov
May 4, 2010·Brain Research Bulletin·Anamika BanerjeeChang-Gyu Hahn
Aug 22, 2009·Neuroscience and Biobehavioral Reviews·Viviane Labrie, John C Roder
Apr 2, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yingjun ZhengHiroyuki Nawa
Oct 24, 2007·Toxicology·Silvia FuentesJosé L Domingo
Apr 25, 2007·Neurobiology of Aging·Mari S GolubPatricia B Hoyer
Feb 24, 2007·Toxicology Letters·Neus Franco-PonsElisabet Vilella
Apr 20, 2005·Journal of Cellular Biochemistry·John J Krolewski
Mar 9, 2005·Annals of the New York Academy of Sciences·Kishorchandra GohilMaret G Traber

❮ Previous
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