Behavioral characteristics of autism spectrum disorder in very preterm birth children

Molecular Autism
Li-Wen ChenChao-Ching Huang

Abstract

Lower gestational age may increase autism spectrum disorder (ASD) vulnerability; however, the incidence of ASD diagnosis through a direct assessment on every very preterm birth child on the population base remains unclear. Moreover, the behavioral characteristics of preterm birth ASD are unknown. Every very preterm birth child (gestational age < 32 weeks; birth weight < 1500 g) who was discharged from neonatal intensive care units in Southern Taiwan and prospectively followed to 5 years of age was evaluated using the Autism Diagnostic Observation Schedule (ADOS) and the Autism Diagnostic Interview-Revised (ADI-R). The term birth (gestational age > 37 weeks) ASD children characterized by ADOS and ADI-R were group matched to the preterm birth ASD by age at examination for comparison. ADOS severity scores were calculated by the Mann-Whitney U test and ADI-R by multivariate analysis of variance and canonical discriminant analysis. Two hundred forty-six (87%) of the 283 very preterm survivors were followed prospectively to 5 years of age. Nineteen (7.7%) of the 246 children fulfilled the diagnostic criteria of ASD. After excluding 1 patient with cerebral palsy and profound mental disability, 18 preterm ASD children were compared wit...Continue Reading

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Citations

Apr 17, 2021·Current Psychiatry Reports·Nicole M McDonald, Shafali S Jeste
May 8, 2021·Molecular Autism·Helen O'ReillyNeil Marlow
Aug 8, 2021·Journal of Neuropathology and Experimental Neurology·Andrée Delahaye-DuriezJuliette Van Steenwinckel

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