Behavioral, cognitive, and safety profile of 2-deoxy-2-glucose (2DG) in adult rats

Epilepsy Research
Jeffrey OckulyCarl Stafstrom

Abstract

2-Deoxy-D-glucose (2DG), a glucose analog that transiently inhibits glycolysis, has anticonvulsant and antiepileptic disease-modifying properties in experimental in vivo models of seizures and epilepsy. Here we evaluated the effects of 2DG across the range of doses (50-500mg/kg i.p.) shown previously to exert anticonvulsant and antiepileptic effects in rats, on spatial learning and memory using the Morris water maze and on exploratory behavior using the open field test. For water maze testing, both acute and chronic protocols were tested. For acute testing, 2DG was injected for 15min prior to the water maze trial only on testing days. For chronic testing, 2DG was injected daily for 14days before water maze testing began. Neither protocol altered the latency to platform acquisition or retention of platform location by the probe test. For open field testing, 2DG was given at doses of 50-250mg/kg 15 or 30min prior to testing on each testing day. When given 30min prior to testing, exploratory activity in the open field was transiently and reversibly decreased by 2DG at doses of 250mg/kg/day but there were no effects on open field activity at 50mg/kg/day. When given 15min prior to testing, 2DG decreased exploratory activity in a dos...Continue Reading

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Citations

Mar 29, 2014·Journal of Neuroinflammation·Anna Vilalta, Guy C Brown
May 16, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Fatima A NasrallahKai-Hsiang Chuang
Nov 5, 2015·Journal of the American Society of Nephrology : JASN·Marco ChiaravalliAlessandra Boletta
May 15, 2013·Journal of Child Neurology·Nika N DanialLiu Lin Thio
Apr 9, 2017·Journal of Nephrology·Riccardo Magistroni, Alessandra Boletta
Oct 19, 2017·Glia·Detlev Boison, Christian Steinhäuser
Sep 29, 2017·Expert Review of Clinical Pharmacology·Iyan Younus, Doodipala Samba Reddy
Nov 12, 2019·American Journal of Physiology. Renal Physiology·Susan GhaziAndrew M Hall
Nov 22, 2018·Frontiers in Cellular Neuroscience·Jenny B Koenig, Chris G Dulla
Jul 16, 2017·Scientific Reports·Glenn DalléracNathalie Rouach
Dec 6, 2020·Nature Communications·B Sofia BeasMario A Penzo
Dec 17, 2020·Frontiers in Neurology·Quirijn P VerhoogErwin A van Vliet

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