PMID: 6410445Jan 1, 1983Paper

Behavioral effects of 5-methoxy-N,N-dimethyltryptamine and dose-dependent antagonism by BC-105

Psychopharmacology
R YoungR A Glennon

Abstract

The discriminative effects of 5-methoxy-N,N-dimethyltryptamine (5-OMeDMT) were studied in rats trained to discriminate 1.5 mg/kg or 3.0 mg/kg 5-OMeDMT from saline. A series of antagonist and generalization tests revealed that (1) antagonism of the 5-OMeDMT stimulus response by the presumed serotonin antagonist BC-105 depended on the dose of 5-OMeDMT, (2) the 5-OMeDMT stimulus generalized to LSD, and (3) like 5-OMeDMT, antagonism of the LSD generalization response by BC-105 depended on the dose of LSD. In a second study, with rats responding under a variable-interval (VI) 15-s schedule of reinforcement, doses of 1.0-3.0 mg/kg 5-OMeDMT significantly decreased response rate. Furthermore, the decrease in responding produced by the administration of 1.5 mg/kg (but not by 3.0 mg/kg) 5-OMeDMT was blocked by BC-105. This dose-dependent antagonism was of particular interest since the 1.5 mg/kg and 3.0 mg/kg dose of 5-O-MeDMT had essentially the same effect on responding when given alone. The results of both studies emphasize the importance of 5-OMeDMT dose in antagonism experiments.

References

Dec 1, 1979·Neuropharmacology·J A Rosecrans, R A Glennon
Jul 1, 1972·European Journal of Pharmacology·K FuxeG Jonsson
Dec 17, 1981·European Journal of Pharmacology·R A GlennonR Young

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Citations

Jan 22, 1985·European Journal of Pharmacology·K A CunninghamJ B Appel
Dec 1, 1986·Pharmacology, Biochemistry, and Behavior·R YoungR A Glennon
Jul 1, 1988·Pharmacology, Biochemistry, and Behavior·J C Winter, R A Rabin
Oct 1, 1988·Pharmacology, Biochemistry, and Behavior·J W Boja, M D Schechter
Dec 1, 1992·Pharmacology, Biochemistry, and Behavior·P A Palumbo, J C Winter
Mar 20, 2002·Pharmacology, Biochemistry, and Behavior·Malgorzata DukatRichard A Glennon
Jul 31, 1998·Progress in Neuro-psychopharmacology & Biological Psychiatry·S HelsleyJ C Winter
Aug 3, 2011·Behavioural Pharmacology·Ian P StolermanKathleen A Grant
Oct 29, 2005·Pharmacology, Biochemistry, and Behavior·Richard YoungRichard A Glennon

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