PMID: 3768722Oct 15, 1986Paper

Behavioral effects of a single neuroleptic treatment grow with the passage of time

Brain Research
S M AntelmanR Stiller

Abstract

The principal finding of this manuscript is that the incidence of catalepsy observed in the rat after a single administration of low, clinically relevant doses of the dopamine receptor antagonists and antipsychotic agents, haloperidol and fluphenazine hydrochloride, grows over time such that one re-exposure to the same compound up to 8 weeks later results in a marked enhancement (i.e. sensitization) of this response. This phenomenon appears to be independent of pharmacokinetic or conditioning factors as well as alterations in dopamine or dihydroxyphenylacetic acid. It suggests that the antidopaminergic influence of acute exposure to a neuroleptic not only persists but continues to sensitize for extraordinary periods of time even after the drug is no longer detectable in the system. Our findings may hold the key to understanding the apparent paradox that although neuroleptics presumably induce their therapeutic actions in disorders such as Tourette syndrome and schizophrenia as well as their parkinsonian effects by blocking dopamine receptors, this antagonism occurs immediately while behavioral changes often require weeks for maximal development.

References

Feb 1, 1980·Psychological Medicine·C D Marsden, P Jenner
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·G L HammondC L Markert
Sep 28, 1981·Life Sciences·A Campbell, R J Baldessarini
Jul 1, 1980·Neuropharmacology·B M CohenR J Baldessarini
Sep 1, 1980·Pharmacology, Biochemistry, and Behavior·T G HeffnerL S Seiden
May 14, 2011·Expert Opinion on Emerging Drugs·Falko Biedermann, W Wolfgang Fleischhacker

❮ Previous
Next ❯

Citations

Jan 1, 1990·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·P J ElliottA S Marriott
Jul 1, 1989·Pharmacology, Biochemistry, and Behavior·S IwataT Fukuda
May 1, 1989·Pharmacology, Biochemistry, and Behavior·S M AntelmanS Knopf
Aug 1, 1990·Pharmacology, Biochemistry, and Behavior·D E BarnesE P Bellows
Aug 1, 1990·Pharmacology, Biochemistry, and Behavior·D Eilam, H Szechtman
Feb 1, 1990·Pharmacology, Biochemistry, and Behavior·D L Wolgin
Apr 1, 1990·Pharmacology, Biochemistry, and Behavior·S FerréM Casas
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·J HietalaM Röyttä
May 1, 1991·Brain Research Bulletin·E P BellowsJ G Csernansky
Nov 5, 1997·Biological Psychiatry·J R StevensP Szot
Mar 29, 2001·Pharmacology, Biochemistry, and Behavior·G LaviolaS Pieretti
Nov 5, 1997·Pharmacology, Biochemistry, and Behavior·S PeciñaL A Parker
Aug 13, 1998·Pharmacology, Biochemistry, and Behavior·K J SnyderL P Spear
Sep 5, 1998·Brain Research. Brain Research Reviews·G L Willis, S M Armstrong
Apr 9, 1998·Progress in Neuro-psychopharmacology & Biological Psychiatry·S M Antelman, S Gershon
Jun 21, 1997·Annals of the New York Academy of Sciences·M M Murburg
May 7, 2008·European Journal of Pharmacology·Mervan S AgovicShailesh P Banerjee
Jan 18, 2005·Neuroscience and Biobehavioral Reviews·Bauke BuwaldaJaap M Koolhaas
Apr 17, 2017·Behavioural Brain Research·Xiaojing DingMing Li
Jun 1, 1995·Journal of Clinical Psychopharmacology·P D KrobothC L Derry
Jul 1, 1992·The International Journal of Neuroscience·G L WillisR Sandyk
Feb 23, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J HietalaE Syvälahti
Apr 6, 2021·The European Journal of Neuroscience·Isabelle WakuAmanda R de Oliveira

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here