Behavioral effects of dehydroepiandrosterone in adult male rats

Progress in Neuro-psychopharmacology & Biological Psychiatry
Julia Fedotova, N S Sapronov

Abstract

It is well-documented that dehydroepiandrosterone (DHEA) exhibits various behavioral effects in rodents, at least one of which is modulation of learning/memory processes in several test paradigms. However, little is known about the influence of DHEA on cognitive performance in the adult rodents. This work was designed to determine whether chronic DHEA administration during 10 days in the high (0.7 mg/kg, s.c.) or low (0.1 mg/kg, s.c.) doses has any effect on learning/memory abilities and behavior in the adult male rats (5- to 6-month old). Effect of DHEA was estimated in active and passive avoidance tasks, behavior was registered in the elevated "plus" maze and the "open field" test. DHEA in the high dose significantly (p<0.05) increased time spent and the number of enterings in the "open" arms of the elevated "plus" maze in intact male rats as compared with the control rats. DHEA in the low dose significantly (p<0.05) decreased horizontal and vertical locomotor activity and grooming behavior, whereas DHEA in the high dose did not significantly modify behavior in intact rats as compared with control group. Results of the ANOVA on passive avoidance performance revealed no statistically significant differences among the groups re...Continue Reading

References

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Citations

Jul 22, 2009·Journal of Endocrinological Investigation·G ValentiR S Schwartz
Jan 13, 2012·The Journal of Nutrition, Health & Aging·M MaggioG P Ceda
Jul 1, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Iván Pérez-NeriCamilo Ríos
Oct 10, 2006·Journal of Psychiatric Research·Bea J M Jogems-KostermanJacques J M van Hoof
Mar 19, 2020·Current Alzheimer Research·Dubravka S StracNela Pivac

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