Behavioral effects of early life maternal trauma witness in rats

Progress in Neuro-psychopharmacology & Biological Psychiatry
Hesong LiuSamina Salim

Abstract

Earlier, we have reported that post-traumatic stress disorder (PTSD)-like behaviors developed in rats that witnessed their cage mates undergo repeated traumatic stress. More recently, we published that early life physical traumatic stress leads to later life depression-like behaviors in rats. Whether early life trauma witness causes later life PTSD-like behaviors is not known. Also unclear are sex-specific stress-induced behavioral variations in later life. The early life witness component of stress is an important aspect of stress-induced psychopathologies and must be investigated. Here, we have examined the impact of early life repeated witnessing of traumatic events by pups from post-natal day (PND) 21-PND27, on later life behaviors at PND60, and the behavioral impact of postpartum traumatic stress in female rats. We used a modified version of rodent social defeat model to induce postpartum stress in female rats and trauma witness stress in pups. One female Sprague-Dawley rat (intruder) was introduced into the cage of an aggressive Long-Evans male rat (resident). The encounter between the two resulted in attacks between the female rat and the Long-Evans male rat. Three exposures of social defeat (attacks) were given for 7 co...Continue Reading

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