Behavioral effects of interleukin-1 beta: modulation by gender, estrus cycle, and progesterone

Brain, Behavior, and Immunity
R AvitsurR Yirmiya

Abstract

Endogenous release or exogenous administration of the cytokine Interleukin-1 (IL-1) produces several behavioral alterations, including suppression of locomotion and exploration. Because there are bidirectional interactions between IL-1 and the hypothalamic-pituitary-gonadal axis, we investigated possible differences between males and females in various phases of the estrus cycle in the behavioral effects of IL-1. In addition, we assessed the role of progesterone in mediating estrus cycle-dependent differences in these effects. Female rats in either the estrus or the non-estrus phase of their cycle and male rats were injected with either IL-1 beta (2 or 5 micrograms/kg) or saline. Activity in the open field test was measured 2 h later by counting the number of line crossings and rearings. In saline-injected rats, nonestrus females performed less line crossings than estrus females. IL-1 produced a significant dose-dependent reduction of line crossing in males and estrus females. In contrast, in nonestrus females the lower dose of IL-1 had no effect, and the effect of the higher dose was significantly smaller in nonestrus than in estrus females. The higher dose of IL-1 suppressed rearing in all three groups, but the effect of the ...Continue Reading

Citations

Sep 1, 2009·Integrative and Comparative Biology·James S Adelman, Lynn B Martin
Aug 29, 2012·Expert Opinion on Therapeutic Targets·Michael MaesRaz Yirmiya
Jan 7, 2017·Pharmacology, Biochemistry, and Behavior·Jonathon SensPothitos M Pitychoutis
Sep 8, 2007·Journal of Applied Physiology·A S BrownE P Mayer
Feb 3, 2015·American Journal of Physical Anthropology·Eric C Shattuck, Michael P Muehlenbein
Jul 30, 2010·Endocrinology·A C Kentner, Q J Pittman
Oct 27, 2018·Military Medical Research·Florian BöschIrshad H Chaudry
Mar 12, 2021·Frontiers in Psychiatry·Caroline J Smith, Staci D Bilbo
Apr 17, 2010·Physiology & Behavior·Lori Asarian, Wolfgang Langhans

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