PMID: 7089039May 1, 1982Paper

Behavioral effects of intracerebroventricularly administered neurohypophyseal hormone analogs in mice

Pharmacology, Biochemistry, and Behavior
G Meisenberg, W H Simmons

Abstract

The neurohypophyseal hormones oxytocin and vasopressin evoke characteristic behavioral changes after intracerebroventricular injection in mice. These included the induction of excessive grooming and scratching in an unrestricted environment and of escape behavior in stressful situations. The structure-activity relations of 33 neurohypophyseal hormones and hormone analogs in the induction of these behavioral changes were examined. The results demonstrate that these effects generally parallel the vasoconstrictory effects of th peptides. It is suggested that the behavioral effects are mediated by a receptor that is closely related biochemically to the vasopressin receptors in blood vessels. They are not related to the long-term effects of neurohypophyseal hormones on learned behavior. A competitive antagonist of the short-term behavioral effects of these peptides is described. This analog also antagonizes some of the hormonal effects of vasopressin and related peptides.

References

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Citations

Jan 1, 1984·Psychopharmacology·A Sahgal
Oct 2, 1990·European Journal of Pharmacology·T B Van Wimersma GreidanusC Maigret
Sep 1, 1991·Physiology & Behavior·F DragoV D'Agata
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·G Meisenberg, W H Simmons
May 1, 1986·Regulatory Peptides·J D CaldwellC A Pedersen
Aug 10, 2001·Physiology & Behavior·L A LumleyJ L Meyerhoff
Jun 18, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ara Schorscher-PetcuJeffrey S Mogil
May 25, 2010·Physiology & Behavior·Jan G VeeningHenk P Barendregt
Jul 1, 1986·Neuropeptides·J D CaldwellC A Pedersen
Jul 1, 1993·Reviews in the Neurosciences·B Alescio-LautierB Soumireu-Mourat
Dec 2, 2016·Current Protocols in Mouse Biology·Stacey J Sukoff Rizzo, Jill L Silverman
Dec 3, 1999·Neuroscience and Behavioral Physiology·N S PonomarevaI P Ashmarin
Mar 29, 2001·Physiological Reviews·G Gimpl, F Fahrenholz
Oct 20, 2020·Frontiers in Neuroscience·Jing GuoYue Hao

Related Concepts

Behavior, Animal
Injections, Intraventricular
Mice, Inbred Strains
Pituitrin
Structure-Activity Relationship

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