Behavioral effects of lead: commonalities between experimental and epidemiologic data

Environmental Health Perspectives
D C Rice

Abstract

Enormous effort has been focused over the last decade and a half on characterizing the behavioral effects of lead in the developing organism. While age-appropriate standardized measures of intelligence (IQ) have been the dependent variable most often used to assess lead-induced cognitive impairment in epidemiologic studies, researchers have also used a variety of other methods designed to assess specific behavioral processes sensitive to lead. Increased reaction time and poorer performance on vigilance tasks associated with increased lead body burden suggest increased distractibility and short attention span. Assessment of behavior on teachers' rating scales identified increased distractibility, impulsivity, nonpersistence, inability to follow sequences of directions, and inappropriate approach to problems as hallmarks of lead exposure. Robust deficits in learned skills such as reading, spelling, math, and word recognition have also been found. Spatial organizational perception and abilities seem particularly sensitive to lead-induced impairment. Assessment of complex tasks of learning and memory in both rats and monkeys has revealed overall deficits in function over a variety of behavioral tasks. Exploration of behavioral mech...Continue Reading

References

Aug 1, 1978·Pharmacology, Biochemistry, and Behavior·L D Chait, R L Balster
May 1, 1979·Pharmacology, Biochemistry, and Behavior·P J Bushnell, R E Bowman
Nov 1, 1979·Journal of Toxicology and Environmental Health·P J Bushnell, R E Bowman
Jan 1, 1979·Toxicology and Applied Pharmacology·D A Cory-Slechta, T Thompson
Jul 1, 1977·Pharmacology, Biochemistry, and Behavior·L HastingsI A Michaelson
Apr 1, 1978·Pharmacology, Biochemistry, and Behavior·H ZenickP Aragon
Jan 1, 1978·Drug and Chemical Toxicology·D D DietzC A Kimmel
Mar 29, 1979·The New England Journal of Medicine·H L NeedlemanP Barrett
Sep 1, 1977·Toxicology and Applied Pharmacology·S R Overmann
Apr 1, 1976·Pharmacology, Biochemistry, and Behavior·J W Driscoll, S E Stegner
Oct 1, 1975·The Journal of Pediatrics·B de la Burdé, M L Choate
Jul 1, 1975·Pharmacology, Biochemistry, and Behavior·K BradyH Zenick
Jul 1, 1992·Neurotoxicology and Teratology·D C Rice
Nov 1, 1990·Environmental Health Perspectives·K N DietrichC R Buncher
Nov 1, 1990·Environmental Health Perspectives·A BhattacharyaR Keith
Feb 2, 1990·JAMA : the Journal of the American Medical Association·H L Needleman, C A Gatsonis
Jan 1, 1990·Toxicology and Applied Pharmacology·D C Rice, S G Gilbert
Apr 1, 1985·American Journal of Public Health·D Rosner, G Markowitz
Dec 1, 1989·American Journal of Public Health·R Rabin
Jul 1, 1989·Journal of Child Psychology and Psychiatry, and Allied Disciplines·G O ThomsonD P Laxen
May 1, 1988·Neurotoxicology and Teratology·D C Rice, K F Karpinski
Nov 1, 1988·Journal of Child Psychology and Psychiatry, and Allied Disciplines·D M FergussonN G Kinzett
Nov 1, 1988·Journal of Child Psychology and Psychiatry, and Allied Disciplines·D M FergussonN G Kinzett
Sep 1, 1988·Journal of Epidemiology and Community Health·N R WiggR J Roberts
Jan 1, 1988·Journal of Child Psychology and Psychiatry, and Allied Disciplines·P A SilvaJ M Faed
Aug 25, 1988·The New England Journal of Medicine·A J McMichaelR J Roberts
Apr 23, 1987·The New England Journal of Medicine·D BellingerM Rabinowitz
May 1, 1987·Archives of Environmental Health·J Schwartz, D Otto
Oct 1, 1987·Environmental Health Perspectives·H L Needleman
Dec 1, 1986·Journal of Clinical and Experimental Neuropsychology·D L MolfeseR J Erwin

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Citations

Apr 1, 1996·Environmental Health Perspectives·D C RiceC Watanabe
Feb 9, 2002·Environmental Health Perspectives·David O CarpenterDavid C Spink
Apr 4, 2006·Environmental Health Perspectives·Shawn A HamidiniaDouglas R Pfeiffer
Jul 17, 2008·Environmental Health Perspectives·Joseph M BraunBruce P Lanphear
Feb 16, 2010·International Journal of Health Geographics·Kate HoffmanVerónica M Vieira
Sep 11, 2010·Environmental Health Perspectives·Paul A EubigSusan L Schantz
Apr 25, 2012·Journal of Molecular Histology·Concepción Nava-RuizCamilo Ríos
Jun 24, 1998·Mutation Research·F M Johnson
Oct 15, 2008·Environmental Monitoring and Assessment·Imtiaz AhmadZia Ur Rehman
Apr 7, 2009·Neurotoxicology and Teratology·Meeyoung O MinSuchitra Nelson
Aug 28, 1998·Environmental Research·D SmithB J Strupp
Jan 6, 2000·Toxicology and Applied Pharmacology·J D CreminD R Smith
Aug 9, 2013·American Journal of Epidemiology·Nadia AbdelouahabLarissa Takser
Aug 13, 2004·Journal of Health and Social Behavior·Paul B Stretesky, Michael J Lynch
May 1, 2001·Current Protocols in Toxicology·T M Burbacher, K S Grant
Sep 7, 2002·Mental Retardation and Developmental Disabilities Research Reviews·Pauline MendolaDeborah Rice
Sep 7, 2002·Mental Retardation and Developmental Disabilities Research Reviews·Andrew S RowlandAnn J Abramowitz
Mar 22, 2019·Journal of Immigrant and Minority Health·Christina D LuponeAndrea Shaw
Dec 1, 2005·Psychological Science in the Public Interest : a Journal of the American Psychological Society·Laura Hubbs-TaitDavid C Bellinger
Oct 25, 2002·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M M Garber, A S Heiman
Oct 4, 2005·Pediatrics·UNKNOWN American Academy of Pediatrics Committee on Environmental Health

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