PMID: 3756503Sep 3, 1986Paper

Behavioral effects of neurotensin in the open field: structure-activity studies

Brain Research
P J ElliottC B Nemeroff

Abstract

The behavioral effects of intracerebroventricularly administered neurotensin (NT), some NT fragments and two synthetic NT analogs were investigated in the open field. Each peptide was studied in both a 'novel' (no pre-exposure) and a 'familiar' (with pre-exposure) environmental situation. Neurotensin decreases locomotor activity in the periphery but increases the time spent in the central area of the apparatus. Of the congeners tested, D-Phe11-NT has similar effects to NT whereas the NT fragments were generally inactive. These findings indicate that the intact peptide or stable substituted NT analogs, but not small C- and N-terminal fragments of NT, are behaviorally active after intraventricular administration.

References

Jan 7, 1977·European Journal of Pharmacology·G R Uhl, S H Snyder
Mar 1, 1979·European Journal of Pharmacology·A J OsbahrA J Prange
Jan 1, 1979·Brain Research Bulletin·K KataokaL A Frohman
Aug 1, 1979·Canadian Journal of Physiology and Pharmacology·J W Phillis, J R Kirkpatrick
Jun 17, 1977·Brain Research·C B NemeroffM A Lipton
Jun 20, 1977·Biochemical and Biophysical Research Communications·L H LazarusJ E Rivier
Nov 1, 1977·Journal of Medicinal Chemistry·J E RivierM R Brown
Sep 20, 1982·The Journal of Comparative Neurology·L JennesP W Kalivas

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Citations

Oct 31, 2015·European Journal of Pharmacology·Xing-Hua ZhenLi-Ping Guan
Jun 15, 2014·Neuropharmacology·Chelsea A VadnieDoo-Sup Choi
Apr 14, 2015·Pharmacology, Biochemistry, and Behavior·Peng JinZhe-Shan Quan
Mar 6, 2015·Frontiers in Systems Neuroscience·Juliette A BrownGina M Leinninger
Jan 1, 1988·Annals of the New York Academy of Sciences·G Bissette, C B Nemeroff
May 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shiben WangZheshan Quan
Feb 19, 2021·Endocrinology·Jariel Ramirez-Virella, Gina M Leinninger

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