PMID: 2124194Oct 1, 1990Paper

Behavioral effects of pre- and postnatal exposure to a mixture of low chlorinated PCBs in rats

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
H LilienthalG Winneke

Abstract

Polychlorinated biphenyl (PCB)-treated Wistar rats were tested on three different behavioral paradigms. Animals were pre- and postnatally exposed to a technical mixture of PCBs with a chlorine content of 42%. Exposure levels were 0, 5, or 30 mg/kg diet. These conditions did not affect the health of the dams, the litter size or weight, or the physical development of the offspring. Relative liver weights in the offspring, however, were elevated in a dose-dependent manner. Open-field ambulation, active avoidance learning, and operant conditioning on a fixed interval 30-sec schedule (FI-30-sec) were used to evaluate PCB-induced behavioral alterations. Ambulation was increased in 30-mg-treated rats at Day 22, but not at Day 120. There were more avoidance responses and intertrial responses in the 30-mg group than in both other groups. On the FI-30-sec schedule slightly more reactions were emitted by the 30-mg group during the first 10 sec of the interval than by the other animals. More pronounced, however, were the differences between groups in the temporal pattern of responses within the 30-sec interval. It is concluded that in rats PCB exposure causes consistent alterations in all of the tested activity-dependent behaviors.

Citations

Jun 6, 1997·Environmental Toxicology and Pharmacology·A Weinand-HärerG Winneke
Jan 6, 2010·Environmental Health Perspectives·Deborah C RiceVincent P Markowski
Apr 1, 1996·Environmental Health Perspectives·D C RiceC Watanabe
Jul 31, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Anne DreiemRichard F Seegal
Sep 11, 2010·Environmental Health Perspectives·Paul A EubigSusan L Schantz
Jul 20, 2002·Neurotoxicology and Teratology·M M TaylorR C MacPhail
May 1, 1996·Neurotoxicology and Teratology·D C Rice
Feb 6, 2007·Hormones and Behavior·Rebecca M SteinbergAndrea C Gore
Feb 21, 2006·Neurotoxicology and Teratology·Cindy S Roegge, Susan L Schantz
Jun 6, 1998·Experimental Neurology·W D NiemiD O Carpenter
Mar 20, 2012·Neurochemistry International·Jordi Boix, Omar Cauli
Nov 1, 1996·Critical Reviews in Toxicology·R F Seegal
Nov 6, 2001·Toxicology and Industrial Health·O FaroonC de Rosa
Oct 7, 2003·Environmental Health Perspectives·Paul StewartPeter Hauser
Jul 28, 2011·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Margarita C Currás-Collazo
Jul 25, 2019·Frontiers in Behavioral Neuroscience·Cristian Perez-FernandezFernando Sánchez-Santed
Dec 21, 2007·The European Journal of Neuroscience·Blanca PiedrafitaVicente Felipo

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