Behavioral effects of the isomers of pentobarbital and secobarbital in mice and rats

Pharmacology, Biochemistry, and Behavior
G R Wenger

Abstract

To determine what stereoselective differences there may be in the behavioral effects of the isomers of pentobarbital and secobarbital, the effect of each isomer was determined on the spontaneous motor activity (SMA) and multiple fixed-ratio 30, fixed-interval 600-sec (mult FR30 FI600) responding of mice, and on the variable-interval 60-sec (VI60) responding of rats. The S-(-) isomers of pentobarbital and secobarbital decreased SMA at lower doses than those required for the R-(+) isomers. At moderate to high doses of R-(+)-pentobarbital (30-42.5 mg/kg) and low to moderate doses of S-(-)-secobarbital (5.6-17.5 mg/kg) SMA was increased. An increase in SMA following R-(+)-secobarbital was only observed at 30 mg/kg, and no increases were observed with S-(-)-pentobarbital. No potency differences were observed between the isomers of pentobarbital and secobarbital on the responding of mice under the mult FR30 FI600 schedule over a dose range of 1-30 mg/kg. Increases in FI600 responding were only observed following moderate doses of the S-(-) isomer of pentobarbital (5.6-17.5 mg/kg). In rats responding under the VI60 schedule of food presentation, no qualitative stereoselective differences were observed in the behavioral effects of the ...Continue Reading

References

Dec 1, 1973·Toxicology and Applied Pharmacology·H D Christensen, I S Lee
Mar 1, 1970·European Journal of Pharmacology·T J Haley, J T Gidley
Aug 19, 1983·European Journal of Pharmacology·H E Shannon, S Herling

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Citations

Oct 1, 1988·Pharmacology, Biochemistry, and Behavior·G R Wenger
Nov 1, 1989·Pharmacology, Biochemistry, and Behavior·K E VanoverW L Woolverton
Jan 1, 1990·Pharmacology & Therapeutics·G T Pollard, J L Howard
Jan 1, 1987·Psychopharmacology·W D Wessinger, G R Wenger
Jul 1, 1995·Journal of the Experimental Analysis of Behavior·D W SchaalA L Odum
Aug 1, 1990·Psychological Medicine·M J Durcan, P F Morgan

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