Behavioral effects of unilateral basal gangliar lesions in neonatal rats

Developmental Psychobiology
C Van Hartesveldt, D Lindquist

Abstract

Two-day-old rats were given unilateral lesions of the caudate-putamen, globus pallidus, or hippocampus and their postural orientation was observed for 30 min immediately after surgery. All groups with damage to the caudate-putamen and/or globus pallidus showed a significant postural deviation toward the side ipsilateral to the lesion. At this age, neurogenesis in the basal ganglia is complete but synapses, neurotransmitters, and enzymes for neurotransmitter synthesis are far below adult levels. These results indicate that the basal ganglia have a role in motor function prior to their full maturation as measured by neuroanatomical and biochemical techniques.

References

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Citations

Jun 1, 1979·Pharmacology, Biochemistry, and Behavior·D L Ormond, C Van Hartesveldt
May 1, 1983·The International Journal of Neuroscience·B S Chozick
Nov 1, 1989·Behavioural Brain Research·F B Weihmuller, J P Bruno

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Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.