Behavioral experience induces zif268 expression in mature granule cells but suppresses its expression in immature granule cells

Frontiers in Systems Neuroscience
Kylie A HuckleberryMichael R Drew

Abstract

Thousands of neurons are born each day in the dentate gyrus (DG), but many of these cells die before reaching maturity. Both death and survival of adult-born neurons are regulated by neuronal activity in the DG. The immediate-early gene (IEG) zif268 appears to be an important mediator of these effects, as its expression can be induced by neural activity and knockout of zif268 impairs survival of adult-born neurons (Richardson et al., 1992; Veyrac et al., 2013). Despite the apparent importance of zif268 for adult neurogenesis, its behavior-induced expression has not been fully characterized in adult-born neurons. Here we characterize behavior-evoked expression of zif268 in mature and newborn dentate granule cells (DGCs). We first quantified zif268 expression in doublecortin-positive (DCX+) immature neurons and in the general granule cell population after brief exposure to a novel environment (NE). In the general granule cell population, zif268 expression peaked 1 h after NE exposure and returned to baseline by 8 h post-exposure. However, in the DCX+ cells, zif268 expression was suppressed relative to home cage for at least 8 h post-exposure. We next asked whether suppression of zif268 in DCX+ immature cells occurs in other behav...Continue Reading

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Citations

Oct 19, 2016·Journal of Neuroscience Research·Miguel Hernández-CerónCarlos Paz
Jul 8, 2017·Hippocampus·Shaina P CahillJason S Snyder
May 11, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Michael R Drew, Kylie A Huckleberry
Jun 27, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kylie A HuckleberryMichael R Drew
Nov 27, 2020·Progress in Neurobiology·Jesse D CushmanFranklin B Krasne

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