Behavioral, Metabolic, and Immune Consequences of Chronic Alcohol or Cannabinoids on HIV/AIDs: Studies in the Non-Human Primate SIV Model

Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology
Patricia E MolinaLiz Simon

Abstract

HIV-associated mortality has been significantly reduced with antiretroviral therapy (ART), and HIV infection has become a chronic disease that frequently coexists with many disorders, including substance abuse (Azar et al. Drug Alcohol Depend 112:178-193, 2010; Phillips et al. J Gen Int Med 16:165, 2001). Alcohol and drugs of abuse may modify host-pathogen interactions at various levels including behavioral, metabolic, and immune consequences of HIV infection, as well as the ability of the virus to integrate into the genome and replicate in host cells. Identifying mechanisms responsible for these interactions is complicated by many factors, such as the tissue specific responses to viral infection, multiple cellular mechanisms involved in inflammatory responses, neuroendocrine and localized responses to infection, and kinetics of viral replication. An integrated physiological analysis of the biomedical consequences of chronic alcohol and drug use or abuse on disease progression is possible using rhesus macaques infected with simian immunodeficiency virus (SIV), a relevant model of HIV infection. This review will provide an overview of the data gathered using this model to show that chronic administration of two of the most commo...Continue Reading

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Citations

Jun 10, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Guy A CabralAron H Lichtman
Feb 23, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jennifer A ManuzakNichole R Klatt
Sep 16, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Rowan SalonerUNKNOWN Translational Methamphetamine AIDS Research Center (TMARC) Group
Jul 30, 2021·ImmunoTargets and Therapy·Valeria GiorgiPiercarlo Sarzi-Puttini
Sep 16, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Liz SimonPatricia E Molina

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