PMID: 6965946Apr 1, 1980Paper

Behavioral methods for inferring anatomical linkage between rewarding brain stimulation sites

Journal of Comparative and Physiological Psychology
P ShizgalJ Yeomans

Abstract

Rats lever pressed for concurrent electrical stimulation of the lateral hypothalamus and ventral tegmentum. The pulse-pair stimulation technique was used, with the first pulse of each pair applied to one electrode and the second to the other electrode; the intrapair interval was varied. The effectiveness of stimulation, measured behaviorally, increased abruptly (within .4 msec) as the intrapair interval was increased in the range from 1.0 to 2.0 msec. These results, which do not resemble single-electrode refractory period results, are interpreted as evidence of collision in the directly stimulated, reward-related neurons linking the two sites. We conclude that self-stimulation of the medial forebrain bundle involves the direct activation of long-axon, longitudinal pathways. Estimates of the conduction velocity in the fibers subserving the collision-like effects are consistent with the properties of small myelinated axons but not central monoaminergic fibers.

Citations

Feb 13, 1984·Brain Research·E Miliaressis, L Philippe
Dec 1, 1982·Physiology & Behavior·J R StellarL E Mills
Jan 1, 1986·Physiology & Behavior·J L MoreauP Karli
Jan 1, 1986·Physiology & Behavior·P A Mason, P M Milner
Aug 1, 1992·Physiology & Behavior·M WaraczynskiP Shizgal
Sep 1, 1995·Physiology & Behavior·M Waraczynski, P Shizgal
Nov 1, 1991·Pharmacology, Biochemistry, and Behavior·E L Gardner, J H Lowinson
Feb 1, 1996·Pharmacology, Biochemistry, and Behavior·F S Hall, J R Stellar
Jan 1, 1996·Neuroscience and Biobehavioral Reviews·L L Bernardis, L L Bellinger
Jan 1, 1987·Pharmacology & Therapeutics·R A Wise
Nov 1, 1995·Brain Research. Brain Research Reviews·J S Yeomans, P W Frankland
Mar 1, 1996·Journal of Neuroscience Methods·E J Tehovnik
Oct 1, 1984·Behavioural Brain Research·G Fouriezos, R A Wise
Sep 1, 1985·Behavioural Brain Research·C Bielajew, G Fouriezos
Aug 1, 1986·Behavioural Brain Research·E MiliaressisD Coulombe
Mar 1, 1987·Behavioural Brain Research·P P Rompré, E Miliaressis
Oct 30, 1990·Behavioural Brain Research·J Malette, E Miliaressis
Mar 31, 1993·Behavioural Brain Research·K E Buckenham, J S Yeomans
Jun 1, 1995·Behavioural Brain Research·J Malette, E Miliaressis
Mar 31, 1994·Behavioural Brain Research·C Bielajew, M Trzcińska

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