PMID: 6976820Jan 14, 1982Paper

Behavioral model for diffuse noxious inhibitory controls (DNIC): potentiation by 5-hydroxytryptophan

Brain Research
E KrausD Le Bars

Abstract

The effects of the serotonin precursor 5-HTP, were determined in a behavioral DNIC paradigm (increase in vocalization threshold after intraperitoneal injection of the algogenic agent, phenylbenzoquinone). This counter-irritation phenomenon was strongly potentiated by 5-HTP, such potentiation being blocked by the 5-HT receptor blocker, cinanserin. These results are in keeping with those of our recent single unit work in dorsal horn convergent neurons.

Citations

Mar 1, 1990·Pharmacology, Biochemistry, and Behavior·B Calvino
Apr 2, 2003·Pharmacology, Biochemistry, and Behavior·Takashi KuriharaTsutomu Tanabe
Mar 20, 2012·Digestive Diseases and Sciences·Jae Woong LeeChong Il Sohn
Jul 2, 2011·The Journal of Pain : Official Journal of the American Pain Society·Roi TreisterElon Eisenberg
Nov 17, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J-M SabatéB Coffin
Mar 8, 2003·Alimentary Pharmacology & Therapeutics·B CoffinD Bouhassira
Jun 11, 2011·Journal of Pain & Palliative Care Pharmacotherapy·Oliver H G Wilder-Smith
Apr 8, 2017·The Journal of Physiology·Kirsty Bannister, A H Dickenson
Apr 29, 2021·Journal of Pain Research·Mateusz Wojciech KucharczykKirsty Bannister

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