PMID: 6770227Jan 1, 1980Paper

Behavioral mutants of Drosophila melanogaster. III. Isolation and mapping of mutations by direct visual observations of behavioral phenotypes

Molecular & General Genetics : MGG
T HomykD T Suzuki

Abstract

Sex-linked behavioral mutants were induced in Drosophila melanogaster with ethyl methanesulfonate (EMS) and isolated by direct visual observation of abnormal phenotypes. The four behavioral phenotypes used were flight-reduction, hyperactivity, hypoactivity and stress-sensitivity, and are easily discernable in either single or small populations of mutant flies. In one screen, forty-two behavioral mutants were recovered from strains derived from 800 mutagen-treated X chromosomes In a second screen, 139 behavioral mutants were obtained from 2369 X chromosomes. The high rate at which behavioral mutants were recovered in the second screen, when compared to new visibles (28) and new temperature-sensitive lethals (124), suggests that the isolation of behavioral mutations on the autosomes of Drosophila and in the genomes of larger insects should be practical.

References

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Citations

May 25, 2013·Annual Review of Neuroscience·Robert B Darnell
Aug 10, 1999·Journal of Neurobiology·Z ZhangR J Wyman
Dec 16, 2003·Invertebrate Neuroscience : in·Ahmet CarhanK G Moffat
Sep 1, 2005·Journal of Genetics·Seema Sisodia, B N Singh
Jul 29, 2004·Journal of Neurobiology·Nick TrottaKendal Broadie
Jul 1, 2005·Physiological Reviews·Scott L Hooper, Jeffrey B Thuma
Nov 14, 2013·Circulation Research·Meera Cozhimuttam ViswanathanAnthony Cammarato
Sep 8, 2010·Developmental Disabilities Research Reviews·Shane L ReaMarni J Falk
May 1, 1982·Quarterly Reviews of Biophysics·J C Hall
Mar 31, 2004·The Journal of Cell Biology·Enrico S Montana, J Troy Littleton
May 12, 2009·Communicative & Integrative Biology·David E FeatherstoneYael Grosjean
May 1, 1993·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Rachel DrysdaleMichael Bate
Dec 27, 1996·The Journal of Biological Chemistry·D ChagnovichS L Cohn
May 2, 2006·Genetics·Tim FergestadB Ganetzky
Apr 19, 2021·Journal of Molecular Biology·Johanna SyrjanenHiro Furukawa
Oct 1, 1998·Behavioural Brain Research·G O Pflugfelder

Related Concepts

Metazoa
Behavior, Animal
Drosophila melanogaster
Ethyl Methanesulfonate
Genetic Equilibrium
Cistron
Genetic Linkage Analysis
Clastogens
Sex Chromosomes
X Chromosome

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