PMID: 6770227Jan 1, 1980Paper

Behavioral mutants of Drosophila melanogaster. III. Isolation and mapping of mutations by direct visual observations of behavioral phenotypes

Molecular & General Genetics : MGG
T HomykD T Suzuki


Sex-linked behavioral mutants were induced in Drosophila melanogaster with ethyl methanesulfonate (EMS) and isolated by direct visual observation of abnormal phenotypes. The four behavioral phenotypes used were flight-reduction, hyperactivity, hypoactivity and stress-sensitivity, and are easily discernable in either single or small populations of mutant flies. In one screen, forty-two behavioral mutants were recovered from strains derived from 800 mutagen-treated X chromosomes In a second screen, 139 behavioral mutants were obtained from 2369 X chromosomes. The high rate at which behavioral mutants were recovered in the second screen, when compared to new visibles (28) and new temperature-sensitive lethals (124), suggests that the isolation of behavioral mutations on the autosomes of Drosophila and in the genomes of larger insects should be practical.


Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·Y N Jan, L Y Jan
Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·O Siddiqi, S Benzer
Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·C F WuS Benzer
Jan 1, 1976·Annual Review of Biophysics and Bioengineering·W L Pak, L H Pinto
Jan 1, 1976·Annual Review of Entomology·F W Plapp
Dec 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·L E Kelly, D T Suzuki
Dec 29, 1972·Nature·Y Hotta, S Benzer
Jan 24, 1973·Molecular & General Genetics : MGG·T A GrigliattiD T Suzuki
Apr 26, 1969·Nature·W L PakN V White
Feb 1, 1951·The Biological Bulletin·L E CHADWICK
Sep 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·S Benzer


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Sep 8, 2010·Developmental Disabilities Research Reviews·Shane L ReaMarni J Falk
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Related Concepts

Behavior, Animal
Drosophila melanogaster
Ethyl Methanesulfonate
Genetic Equilibrium
Genetic Linkage Analysis
Sex Chromosomes
X Chromosome

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