PMID: 8597429Dec 29, 1995Paper

Behavioral, neurochemical, and immunological responses to CRF administration. Is CRF a mediator of stress?

Annals of the New York Academy of Sciences
C SongB E Leonard

Abstract

The effect of subacute intracerebroventricular (icv 0.1, 0.5, and 1.0 microgram) administration of corticotropin-releasing factor (CRF) for 5 days on behavior, neurotransmitter concentrations, and immune functions was studied in rats. The results showed that CRF administration produced a dose-dependent increase in locomotor activity in the "open field" test compared with controls; rearing scores were also significantly increased. In the elevated plus maze apparatus, rats given 1.0 microgram CRF spent considerably less time on the open arms when compared with controls. Following 0.5 and 1.0 microgram of CRF infusion, the concentrations of noradrenaline (NA), dopamine (DA) and 5-hydroxy indole acetic acid (5-HIAA) were significantly increased in the hypothalamus. There was no significant change in the concentrations of neurotransmitters in the other brain regions. CRF administration also produced a dose-dependent increase in the levels of corticosterone in the serum. The immunological results clearly showed that subacute icv CRF administration caused a reduction of lymphocyte proliferation, a decrease in the percentage of lymphocytes, and an increase in neutrophil percentage in the differential white blood cell (WBC) count, a dec...Continue Reading

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Citations

Apr 1, 1997·Pharmacology, Biochemistry, and Behavior·C SongB E Leonard
Aug 22, 2001·Peptides·E BujdosóG Telegdy
Aug 26, 1998·Drug and Alcohol Dependence·D W Self, E J Nestler
Aug 11, 2004·Behavioral Neuroscience·Stephen C GammieJustin S Rhodes
Feb 5, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Emily G LoweryTodd E Thiele
Aug 26, 2014·Brain, Behavior, and Immunity·Dervla O'MalleyTimothy G Dinan
Aug 19, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ines KaufmannManfred Thiel
Sep 12, 2009·Cellular Immunology·Maria Cristina Dos-SantosAlvaro L Bertho
Aug 1, 2002·Acta Neuropsychiatrica·Brian E Leonard
Feb 25, 2009·Annals of the New York Academy of Sciences·Frederico Azevedo Costa-PintoJoao Palermo-Neto
Mar 10, 2012·The Journal of Pharmacology and Experimental Therapeutics·Donald R GehlertS Michelle Morin
Feb 7, 2006·European Psychiatry : the Journal of the Association of European Psychiatrists·B E Leonard
Jun 14, 2017·Reviews in the Neurosciences·Robert Lalonde, Catherine Strazielle
Feb 28, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J ManningD O'Malley
Nov 27, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Dervla O'MalleyJohn F Cryan
Feb 22, 2003·CNS Drug Reviews·Patricia A SeymourDavid W Schulz
Oct 26, 2007·Neurochemical Research·Fiona Thomson, Mark Craighead
Mar 10, 2020·Advances in Nutrition·Tracey L K BearPramod K Gopal

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