Behavioral outcomes in children exposed prenatally to lamotrigine, valproate, or carbamazepine

Neurotoxicology and Teratology
Uma DeshmukhLewis B Holmes

Abstract

To evaluate adaptive behavior outcomes of children prenatally exposed to lamotrigine, valproate, or carbamazepine, and to determine if these outcomes were dose-dependent. Data were collected from women enrolled in the North American Anti epileptic Drug (AED) Pregnancy Registry who had taken lamotrigine, valproate, or carbamazepine monotherapies throughout pregnancy to suppress seizures. The adaptive behavior of 252 exposed children (including 104 lamotrigine-exposed, 97 carbamazepine-exposed, and 51 valproate-exposed), ages 3- to 6-years-old, was measured using the Vineland-II Adaptive Behavior Scales, administered to each mother by telephone. Mean Adaptive Behavior Composite (ABC), domain standard scores for communication, daily living, socialization and motor skills, and adaptive levels were analyzed and correlated with first trimester drug dose. After adjusting for maternal age, education, folate use, cigarette and alcohol exposure, gestational age, and birth weight by propensity score analysis, the mean ABC score for valproate-exposed children was 95.6 (95% CI [91, 101]), versus 100.8 (95% CI [98, 103]) and 103.5 (95% CI [101, 106]) for carbamazepine- and lamotrigine-exposed children, respectively (ANOVA; p=0.017). Signific...Continue Reading

References

Jan 1, 1988·American Journal of Medical Genetics·H H ArdingerE J Lammer
Nov 30, 1999·Annals of Neurology·E B SamrénD Lindhout
Jul 7, 2000·Journal of Medical Genetics·S J MooreJ C Dean
Dec 16, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·N AdabD Chadwick
Dec 5, 2002·Seizure : the Journal of the British Epilepsy Association·George MawerUsha Kini
Oct 20, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·N AdabD W Chadwick
Mar 23, 2005·Neurology·J VintenUNKNOWN Liverpool and Manchester Neurodevelopment Study Group
Mar 23, 2005·Neurology·D F WyszynskiUNKNOWN Antiepileptic Drug Pregnancy Registry
Mar 30, 2005·Expert Opinion on Drug Safety·Rachel Alsdorf, Diego F Wyszynski
Mar 31, 2005·Journal of Autism and Developmental Disorders·Annelies de BildtRuud Minderaa
Aug 20, 2005·Developmental Medicine and Child Neurology·A D RasalamJ C S Dean
Sep 15, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·J MorrowJ Craig
Dec 3, 2005·Pediatrics·David S MandellCynthia D Zubritsky
Aug 9, 2006·Neurology·K J MeadorUNKNOWN NEAD Study Group
Oct 20, 2006·Epilepsy & Behavior : E&B·Katriina ViinikainenReetta Kälviäinen
Jan 8, 2008·Developmental Medicine and Child Neurology·Karl TitzeHans-Christoph Steinhausen
Mar 19, 2008·Epilepsy & Behavior : E&B·Sanjeev V ThomasP S Sarma
Nov 11, 2008·Epilepsy & Behavior : E&B·J VintenUNKNOWN Liverpool and Manchester Neurodevelopment Group
Dec 3, 2008·Neurology·R L BromleyUNKNOWN Liverpool and Manchester Neurodevelopment Group
Nov 3, 2010·Journal of Autism and Developmental Disorders·Stephen M KanneCeline A Saulnier
Jan 13, 2011·Brain : a Journal of Neurology·Kimford J MeadorUNKNOWN NEAD Study Group
Jan 26, 2011·Neurology·R ShallcrossUNKNOWN UK Epilepsy and Pregnancy Register
Mar 19, 2011·Archives of Disease in Childhood·Cliona CummingsJoanne Nelson
Jul 26, 2011·Epilepsy & Behavior : E&B·Morris J CohenDavid W Loring
Feb 2, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Rebecca Louise BromleyUNKNOWN Liverpool and Manchester Neurodevelopment Group
Sep 10, 2013·Epilepsy & Behavior : E&B·Morris J CohenUNKNOWN NEAD study group
Dec 30, 2014·Neurology·Gus A BakerUNKNOWN Liverpool and Manchester Neurodevelopment Group

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Citations

Oct 21, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Page B Pennell
Oct 28, 2016·Seizure : the Journal of the British Epilepsy Association·Rebecca L Bromley, Gus A Baker
Aug 22, 2017·The Australian and New Zealand Journal of Psychiatry·Carolyn Haskey, Megan Galbally
Jun 13, 2018·Journal of Perinatal Medicine·Toshiyuki HataTakashi Kusaka
Jan 22, 2019·Current Opinion in Neurology·Torbjörn TomsonEmilio Perucca
Mar 29, 2019·Continuum : Lifelong Learning in Neurology·Mona Sazgar
Dec 5, 2019·Journal of Women's Health·Hannah K Betcher, Katherine L Wisner
May 28, 2016·Current Neurology and Neuroscience Reports·H Steven Block
Sep 27, 2018·Clinical Pharmacokinetics·Michael PaulzenGeorgios Schoretsanitis

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