Behavioral Paradigms to Probe Individual Mouse Differences in Value-Based Decision Making

Frontiers in Neuroscience
Opeyemi O AlabiMarc V Fuccillo

Abstract

Value-based decision making relies on distributed neural systems that weigh the benefits of actions against the cost required to obtain a given outcome. Perturbations of these systems are thought to underlie abnormalities in action selection seen across many neuropsychiatric disorders. Genetic tools in mice provide a promising opportunity to explore the cellular components of these systems and their molecular foundations. However, few tasks have been designed that robustly characterize how individual mice integrate differential reward benefits and cost in their selection of actions. Here we present a forced-choice, two-alternative task in which each option is associated with a specific reward outcome, and unique operant contingency. We employed global and individual trial measures to assess the choice patterns and behavioral flexibility of mice in response to differing "choice benefits" (modeled as varying reward magnitude ratios) and different modalities of "choice cost" (modeled as either increasing repetitive motor output to obtain reward or increased delay to reward delivery). We demonstrate that (1) mouse choice is highly sensitive to the relative benefit of outcomes; (2) choice costs are heavily discounted in environments...Continue Reading

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Citations

Oct 31, 2020·Current Biology : CB·Cathy S ChenNicola M Grissom
May 4, 2021·Current Opinion in Neurobiology·Tara Raam, Weizhe Hong

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