Abstract
ATP-sensitive potassium (K(ATP)) channels are expressed in various tissues and cell-types where they act as so-called metabolic sensors that couple metabolic state to cellular excitability. The pore of most K(ATP) channel types is built by Kir6.2 subunits. Analysis of a general Kir6.2 knockout (KO) mouse has identified a variety of different functional roles for central and peripheral K(ATP) channels in situations of metabolic demand. However, the widespread distribution of these channels suggests that they might influence cellular physiology and animal behavior under metabolic control conditions. As a comprehensive behavioral description of Kir6.2 KO mice under physiological control conditions has not yet been carried out, we subjected Kir6.2 KO and corresponding wild-type (WT) mice to a test battery to assess emotional behavior, motor activity and coordination, species-typical behaviors and cognition. The results indicated that in these test situations Kir6.2 KO mice were less active, had impaired motor coordination, and appeared to differ from controls in their emotional reactivity. Differences between KO and WT mice were generally attenuated in test situations that resembled the home cage environment. Moreover, in their hom...Continue Reading
References
Jan 1, 1987·Psychopharmacology·R G Lister
Aug 1, 1980·Pharmacology, Biochemistry, and Behavior·J Crawley, F K Goodwin
May 1, 1996·Behavioural Brain Research·M T BardoN G Harrington
Oct 8, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·D C RogersJ E Martin
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·T MikiS Seino
Aug 28, 1999·Neuroscience·M R StefaniP E Gold
Sep 21, 2000·Behavioural Brain Research·M M van Gaalen, T Steckler
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·X ZhuangR Hen
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·C Hernández-SánchezD LeRoith
May 26, 2001·Science·K YamadaN Inagaki
Jun 26, 2001·Behavioural Brain Research·C ContetR M Deacon
Jul 4, 2001·Neuroreport·R M DeaconJ N Rawlins
May 9, 2002·Behavioural Brain Research·Robert M J DeaconJ Nicholas P Rawlins
Sep 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Leonid V ZingmanAndre Terzic
Feb 5, 2003·Progress in Biophysics and Molecular Biology·Susumu Seino, Takashi Miki
Aug 15, 2003·American Journal of Physiology. Cell Physiology·B GongJ M Renaud
Nov 25, 2004·Diabetes·Joseph BryanLydia Aguilar-Bryan
Nov 25, 2004·Diabetes·Garvan C KaneAndre Terzic
Nov 25, 2004·Diabetes·Kohtaro MinamiSusumu Seino
Dec 8, 2004·Behavioural Brain Research·Robert M J Deacon, J Nicholas P Rawlins
Aug 3, 2005·The Journal of Clinical Investigation·Frances M Ashcroft
Nov 22, 2005·Nature Neuroscience·Birgit LissJochen Roeper
Citations
Aug 21, 2012·Nature Neuroscience·Julia SchiemannJochen Roeper
Sep 24, 2013·PloS One·Thashi ChangAngela Vincent
Jan 20, 2012·Journal of Visualized Experiments : JoVE·Robert Deacon
Jun 12, 2013·Journal of Visualized Experiments : JoVE·Robert M J Deacon
Jun 19, 2013·Journal of Visualized Experiments : JoVE·Robert M J Deacon
Jun 3, 2011·Journal of Visualized Experiments : JoVE·Rob M J Deacon
Jul 16, 2013·Journal of Visualized Experiments : JoVE·Robert M J Deacon
Jun 20, 2015·Psychiatry Research·Adela ViggianoDavide Viggiano
Nov 21, 2015·Journal of Neuroinflammation·David Chun-Hei PoonRaymond Chuen-Chung Chang
Aug 1, 2015·Behavioural Neurology·Karla Salgado-PugaFernando Peña-Ortega
Jan 24, 2015·Neuromolecular Medicine·Robert M J DeaconPatricia Cogram
Dec 17, 2009·International Journal of Radiation Oncology, Biology, Physics·Kai-Liang WuC Shun Wong
Dec 19, 2009·Physiology & Behavior·Deike HesseJan Rozman
Apr 18, 2009·Behavioural Brain Research·R M J Deacon
Jul 29, 2008·Behavioural Brain Research·Davide Viggiano
Feb 13, 2016·Journal of Neurochemistry·Johanna DudaBirgit Liss
Aug 28, 2020·The International Journal of Neuroscience·Maham SanawarTariq Ismail
Feb 16, 2021·Frontiers in Pharmacology·Nanshan SongMing Lu
Feb 13, 2018·Physiology & Behavior·Atsumi SaitoHiroshi Takeda
Mar 23, 2017·Science Signaling·Giannina DescalziVenetia Zachariou
Nov 5, 2021·Proceedings of the National Academy of Sciences of the United States of America·Shaul YahilMaria S Remedi