Behavioral phenotyping of mice lacking the K ATP channel subunit Kir6.2

Physiology & Behavior
R M DeaconBirgit Liss

Abstract

ATP-sensitive potassium (K(ATP)) channels are expressed in various tissues and cell-types where they act as so-called metabolic sensors that couple metabolic state to cellular excitability. The pore of most K(ATP) channel types is built by Kir6.2 subunits. Analysis of a general Kir6.2 knockout (KO) mouse has identified a variety of different functional roles for central and peripheral K(ATP) channels in situations of metabolic demand. However, the widespread distribution of these channels suggests that they might influence cellular physiology and animal behavior under metabolic control conditions. As a comprehensive behavioral description of Kir6.2 KO mice under physiological control conditions has not yet been carried out, we subjected Kir6.2 KO and corresponding wild-type (WT) mice to a test battery to assess emotional behavior, motor activity and coordination, species-typical behaviors and cognition. The results indicated that in these test situations Kir6.2 KO mice were less active, had impaired motor coordination, and appeared to differ from controls in their emotional reactivity. Differences between KO and WT mice were generally attenuated in test situations that resembled the home cage environment. Moreover, in their hom...Continue Reading

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Citations

Jan 20, 2012·Journal of Visualized Experiments : JoVE·Robert Deacon
Jun 12, 2013·Journal of Visualized Experiments : JoVE·Robert M J Deacon
Jun 19, 2013·Journal of Visualized Experiments : JoVE·Robert M J Deacon
Jun 3, 2011·Journal of Visualized Experiments : JoVE·Rob M J Deacon
Jul 16, 2013·Journal of Visualized Experiments : JoVE·Robert M J Deacon
Nov 21, 2015·Journal of Neuroinflammation·David Chun-Hei PoonRaymond Chuen-Chung Chang
Aug 1, 2015·Behavioural Neurology·Karla Salgado-PugaFernando Peña-Ortega
Jan 24, 2015·Neuromolecular Medicine·Robert M J DeaconPatricia Cogram
Dec 17, 2009·International Journal of Radiation Oncology, Biology, Physics·Kai-Liang WuC Shun Wong
Aug 28, 2020·The International Journal of Neuroscience·Maham SanawarTariq Ismail
Nov 5, 2021·Proceedings of the National Academy of Sciences of the United States of America·Shaul YahilMaria S Remedi

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