Behavioral signs of axial low back pain and motor impairment correlate with the severity of intervertebral disc degeneration in a mouse model

The Spine Journal : Official Journal of the North American Spine Society
Magali MillecampsLaura S Stone

Abstract

Chronic low back pain is debilitating and difficult to treat. Depending on the etiology, responses to treatments vary widely. Although chronic low back pain is frequently related to intervertebral disc degeneration, the relationship between disc degeneration severity and clinical symptoms are still poorly understood. In humans, studies investigating the relationship between disc degeneration severity and low back pain are limited by the difficulty of obtaining disc samples from well-characterized patients and pain-free controls. We have previously described the secreted protein, acidic, rich in cysteine (SPARC)-null mouse model of chronic low back pain. SPARC is a matricellular protein involved in regulating the assembly and composition of extracellular matrix. The SPARC-null mice develop age-dependent disc degeneration of increasing severity accompanied by behavioral signs suggestive of axial low back pain, radiating leg pain, and motor impairment. The existence of this model allows for examination of the relationships between clinical symptoms in vivo and pathological signs of disc degeneration ex vivo. The goal of this study was to explore the relationship between behavioral signs of pain and the severity of lumbar disc dege...Continue Reading

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Citations

Aug 30, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Martha E ZeemanBeth A Winkelstein
Jan 25, 2017·Scoliosis and Spinal Disorders·Dino Samartzis, Theodoros B Grivas
Jun 21, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Takashi OhnishiNorimasa Iwasaki
Dec 10, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Seunghwan LeeLaura S Stone
Sep 17, 2017·Oncotarget·Zhi-Hua OuyangGuo-Hua Lv
May 11, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Rahul GawriRita Kandel
Jun 4, 2019·The Journal of Orthopaedic and Sports Physical Therapy·Paul W HodgesLaura S Stone
Sep 3, 2020·Journal of Orthopaedic Surgery and Research·Shiyu HuTao Lan
Jan 1, 2020·JOR Spine·Andrew BratsmanFlorent Elefteriou
Feb 10, 2019·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·G JamesP W Hodges
Jul 3, 2020·JOR Spine·Juliane D GlaeserDmitriy Sheyn
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Mar 24, 2021·Arthritis Research & Therapy·Geoffrey J KerrCheryle A Séguin
Jun 12, 2021·The Spine Journal : Official Journal of the North American Spine Society·Yuya KawaraiLaura S Stone
Jul 4, 2021·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Magali MillecampsLaura S Stone

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