PMID: 16619523Apr 20, 2006Paper

Behavioral stress and tumor progression

Anticancer Research
Jennifer P Montgomery, Paul H Patterson

Abstract

A number of laboratories have reported a possible link between behavioral stress and cancer progression. Previously published findings demonstrated a stress-induced increase in tumor growth of implanted lymphosarcoma in C3H mice. Here, two mouse models were utilized to investigate whether stress alters the growth of solid tumors. We developed a stress paradigm that involves alternating established stressors for 12 days. FVB mice implanted with melanoma were subjected to this stress protocol. We also attempted to duplicate Riley's finding. Our stress paradigm markedly increased serum corticosterone levels and thymus involution. No alteration in the growth of the melanoma tumors was observed. There was also no significant effect on lymphosarcoma progression using either our own or Riley's stress protocol. Under the conditions used in this study, strong behavioral stress did not influence tumor progression.

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.