Abstract
The spectrum of abnormal behaviors in amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) has been described, but its practical meaning, namely its impact on caregiver burden, has not been clearly documented in Chinese population. This study aimed to assess the distribution of abnormal behaviors in Chinese population, and to analyze the relationship between behavior changes and caregiver burden. Sixty-five patients with ALS/MND have been consecutively enrolled into registry platform of Peking Union Medical College Hospital. An investigation was performed to these patients and their caregivers using the revised ALS function rating scale, Frontal Behavioral Inventory-ALS version, the Frontal Assessment Battery, and the Caregiver Burden Inventory. Twenty-eight (43.1%) patients displayed abnormal behaviors of varying degrees, with one fulfilling the diagnostic criteria of frontotemporal lobe degeneration. Irritability, logopenia, and inflexibility ranked top 3 of abnormal behavior list. Correlation analysis revealed that the degree of behavioral change and frontal cognitive status were significantly associated with caregiver burden, with more extensive impact from disinhibitive behaviors. Analysis of covariance analysis sh...Continue Reading
References
Jan 1, 1989·Neuroepidemiology·A D HillelN Konikow
Dec 17, 1998·Neurology·D NearyD F Benson
Dec 14, 1999·Journal of the Neurological Sciences·J M CedarbaumA Nakanishi
Dec 13, 2000·Neurology·B DuboisB Pillon
Jul 24, 2001·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·B R BrooksUNKNOWN World Federation of Neurology Research Group on Motor Neuron Diseases
Sep 28, 2002·Nursing Research·Kuei-Ru ChouHsin Chu
Aug 12, 2004·Dementia and Geriatric Cognitive Disorders·J C MourikA Tibben
Jul 5, 2005·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·I AppollonioP Nichelli
Aug 24, 2005·Neurology·G M RingholzP E Schulz
Feb 24, 2006·Psychological Medicine·L H GoldsteinP N Leigh
Mar 21, 2007·Neurology·A GauthierA Chiò
Apr 11, 2007·Archives of Neurology·Jeldican VisserMarianne de Visser
Oct 20, 2007·Lancet Neurology·Julie PhukanOrla Hardiman
Nov 6, 2008·Dementia and Geriatric Cognitive Disorders·K M KnutsonJ Grafman
Apr 21, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A ChiòA Montuschi
Jul 14, 2010·Archives of Neurology·Patricia LilloJohn R Hodges
Sep 21, 2010·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Patricia LilloJohn R Hodges
Apr 5, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Keith A JosephsClifford R Jack
Jul 26, 2011·Journal of the Neurological Sciences·Tatsuhiro TeradaKouichi Mizoguchi
Aug 13, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·Julie PhukanOrla Hardiman
Mar 20, 2012·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Joost RaaphorstBen Schmand
Dec 12, 2012·BMC Neurology·Patricia LilloJohn R Hodges
Dec 25, 2012·Neurobiology of Aging·Zhang-Yu ZouLi-Ying Cui
Jul 4, 2013·Acta Neurologica Scandinavica·M S LiuUNKNOWN Chinese ALS Association
Feb 6, 2014·PloS One·Seong-il OhSeung Hyun Kim
Feb 12, 2014·Acta Neuropathologica·Ione O C Woollacott, Simon Mead
Apr 3, 2014·Acta Neurologica Scandinavica·F CuiL Wang
Apr 29, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Anna MontuschiAdriano Chiò
Sep 25, 2014·Journal of Neurology·QianQian WeiHui-Fang Shang
Citations
Nov 23, 2016·Journal of Clinical Nursing·Dan GengRong Yang
Oct 30, 2018·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Jashelle CagaMatthew C Kiernan
Apr 16, 2019·International Psychogeriatrics·Tina KarnatzJochen René Thyrian
Mar 12, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Isabel K GosseltMichael A Van Es
Jun 21, 2017·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Mattia SicilianoGioacchino Tedeschi
Dec 1, 2017·Journal of Neurology·J CagaM C Kiernan
Jan 14, 2021·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Jashelle CagaOlivier Piguet