Behavioral toxicology of carbon disulfide and toluene

Environmental Health Perspectives
B WeissD A Macys

Abstract

Organic solvents are pervasive in the communal and industrial environments. Although many are potent central nervous system agents, clearly delineated behavioral effects have played only a minor role in the formation of exposure standards. A comprehensive behavioral pharmacology and toxicology of these compounds is one aim of US/USSR collaboration. The current report describes some actions of carbon disulfide and toulene. Earlier data about the actions of carbon disulfide on pigeon operant performance indicated disruption of schedule-controlled key-pecking. Primate data are now described from a situation designed to determine aversive thresholds to electrical stimulation. Effective concentrations of carbon disulfide produced both a rise in the amount of electric shock tolerated and a diminution of the response force exerted by the monkeys. In experiments with toluene, pigeons were shown to elevate key-pecking rate in an operant situation at certain concentrations. Toluene also was studied for its capacity to maintain self-administration in the same way as drugs of abuse. Monkeys worked to gain access to toulene vapor just as they work for opiates or amphetamines. The current experiments demonstrate how comprehensive the range o...Continue Reading

References

Sep 1, 1976·Journal of the Experimental Analysis of Behavior·J W McKearney
Jan 1, 1975·The International Journal of the Addictions·G L Schmidt
Feb 1, 1976·Environmental Health Perspectives·B Weiss, T E Levine
Jan 1, 1969·Annual Review of Pharmacology·C R Schuster, T Thompson
Dec 29, 1966·The New England Journal of Medicine·J W Knox, J R Nelson
Dec 19, 1958·Science·B WEISS, V G LATIES
Jul 1, 1963·Journal of the Experimental Analysis of Behavior·F Mechner, M LATRANYI
Apr 1, 1958·Journal of the Experimental Analysis of Behavior·F Mechner

Citations

Dec 11, 2013·Psychopharmacology·Alec Lindsay Ward DickJhodie Rubina Duncan
Jun 1, 1988·British Journal of Industrial Medicine·R KishiH Miyake
Aug 31, 2002·Environmental Toxicology·Xiaodong TanPhilippe Hartemann
Sep 1, 1994·Archives of Environmental Health·T C MorataW K Sieber
Jul 1, 1994·Archives of Environmental Health·M VanhoorneD De Bacquer
Apr 4, 2002·Nuclear Medicine and Biology·Ryan D MullerV Garza
Mar 18, 1999·Pharmacology, Biochemistry, and Behavior·A C Riegel, E D French
Aug 1, 1987·Pharmacology, Biochemistry, and Behavior·T K GhoshS N Pradhan
Sep 25, 2002·Life Sciences·Madina R GerasimovStephen L Dewey
Mar 1, 1982·Environmental Monitoring and Assessment·J K Piotrowski, J M Buchanan
May 14, 1984·Toxicology·T M ReaW V Kessler
Jan 1, 1983·Critical Reviews in Toxicology·R O BeauchampL Goldberg
Jul 23, 1999·Toxicology and Industrial Health·W R RogersL Bunegin
Jun 5, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A C RiegelE D French
Aug 21, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jacob T Beckley, John J Woodward
Jun 1, 1979·Environmental Health Perspectives·P E SchambraN N Litvinov
Jan 11, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Arthur C RiegelE D French
Jun 8, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Wesley N Wayman, John J Woodward
Feb 1, 1982·British Journal of Industrial Medicine·H Sakurai
Sep 26, 2020·Frontiers in Neuroscience·Kevin M BraunscheidelJohn J Woodward
Jun 26, 2001·ILAR Journal·L Williams, M Glasgow

Related Concepts

Metazoa
Anthropoidea
Atmosphere Exposure Chambers
Behavior, Animal
Carbon Disulfide
Environmental Exposure
Information Specialists
Treaties
National Library of Medicine (U.S.)
Columba livia

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