Behavioral toxicology, risk assessment, and chlorinated hydrocarbons

Environmental Health Perspectives
A M Evangelista de Duffard, R Duffard

Abstract

Behavioral end points are being used with greater frequency in neurotoxicology to detect and characterize the adverse effects of chemicals on the nervous system. Behavioral measures are particularly important for neurotoxicity risk assessment since many known neurotoxicants do not result in neuropathology. The chlorinated hydrocarbon class consists of a wide variety of chemicals including polychlorinated biphenyls, clioquinol, trichloroethylene, hexachlorophene, organochlorine insecticides (DDT, dicofol, chlordecone,dieldrin, and lindane), and phenoxyherbicides. Each of these chemicals has effects on motor, sensory, or cognitive function that are detectable using functional measures such as behavior. Furthermore, there is evidence that if exposure occurs during critical periods of development, many of the chlorinated hydrocarbons are developmental neurotoxicants. Developmental neurotoxicity is frequently expressed as alterations in motor function or cognitive abilities or changes in the ontogeny of sensorimotor reflexes. Neurotoxicity risk assessment should include assessments of the full range of possible neurotoxicological effects, including both structural and functional indicators of neurotoxicity.

References

Mar 1, 1977·Archives of Dermatology·L M SolomonD P West
Jun 1, 1978·American Journal of Epidemiology·S B CannonJ A Liddle
Feb 1, 1978·Food and Cosmetics Toxicology·Y MasudaM Kuratsune
Jan 1, 1979·Archives of Environmental Contamination and Toxicology·M de Campos, A E Olszyna-Marzys
Apr 1, 1978·Toxicology·L R WeissS Krop
Dec 1, 1992·Mutation Research·R ForsterJ Westendorf
Feb 1, 1992·Archives of Environmental Contamination and Toxicology·Y K MatuoJ L Lopes
Jan 1, 1992·Neurotoxicology and Teratology·E S Goldey, D H Taylor
Jul 1, 1991·Journal of Toxicology and Environmental Health·J E Lessenger, N Riley
May 1, 1990·Neurotoxicology and Teratology·H A TilsonW J Rogan
Jun 1, 1990·Scandinavian Journal of Work, Environment & Health·J OlsenH Kolstad
Mar 30, 1987·Toxicology and Applied Pharmacology·H A TilsonR L McLamb
Sep 15, 1989·Toxicology and Applied Pharmacology·K EckolsL Uphouse
Nov 1, 1989·Neurotoxicology and Teratology·A Seeber
Jul 1, 1989·Archives of Environmental Contamination and Toxicology·R H HillS Binder
Dec 1, 1987·Neurochemical Research·R O DuffardA M Evangelista de Duffard
Jan 1, 1988·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·H A EloP Ylitalo
Jan 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·J A HeyM C Koss
Sep 1, 1988·Toxicology and Industrial Health·B Weiss
Oct 1, 1988·Toxicology Letters·B Weiss
Nov 1, 1987·Neurotoxicology and Teratology·H A Tilson
Mar 1, 1987·Acta paediatrica Scandinavica·S S Atuma, D I Okor
Dec 1, 1985·Regulatory Toxicology and Pharmacology : RTP·F Coulston
Feb 1, 1985·Environmental Health Perspectives·R D Kimbrough
Aug 1, 1985·Child Development·S W JacobsonJ K Dowler
Aug 7, 1971·Lancet·A CurleyL Finberg
Jan 1, 1974·Internationales Archiv Für Arbeitsmedizin·I Dési
Dec 4, 1971·Lancet·J TateishiS Otsuki
Jan 1, 1973·Drugs·V D Plueckhahn
Jan 1, 1969·Annual Review of Pharmacology·B Weiss, V G Laties
Aug 1, 1971·Archives of Environmental Health·R D Kimbrough, T B Gaines
Jun 1, 1969·Archives of Environmental Health·R J Vernon, R K Ferguson
Mar 1, 1982·Journal of Dairy Science·M C Saxena, M K Siddiqui
Jan 1, 1982·Annual Review of Pharmacology and Toxicology·P S Guzelian

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Citations

Oct 31, 2001·Phytochemistry·R Vázquez-DuhaltF J Márquez-Rocha
Mar 10, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Ryo KamataHiroaki Shiraishi
Jul 15, 2009·Toxicology Letters·Wei-Hung ChanTzuu-Huei Ueng
Sep 20, 2005·Ecotoxicology and Environmental Safety·Sheri A FisherJudit E Smits
Jun 6, 2015·Journal of Pharmacological and Toxicological Methods·David V GauvinTheodore J Baird
Jun 5, 2015·Mutation Research. Reviews in Mutation Research·Nikolai L ChepelevCarole L Yauk
Apr 15, 2015·International Journal of Hygiene and Environmental Health·Franziska Maria PutschöglJessica Lang
Oct 10, 2001·Progress in Lipid Research·R J HeathC O Rock
May 12, 2006·Critical Reviews in Toxicology·E Mariussen, F Fonnum
Aug 26, 2006·Water Environment Research : a Research Publication of the Water Environment Federation·George A Ehlers, Peter D Rose
Apr 13, 2019·Acta Neuropathologica·Isaac N PessahSharon K Sagiv
Sep 28, 2017·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Judy S LaKindMichael Goodman

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