Behaviorally activated mRNA expression profiles produce signatures of learning and enhanced inhibition in aged rats with preserved memory

PloS One
Rebecca HabermanMichela Gallagher

Abstract

Aging is often associated with cognitive decline, but many elderly individuals maintain a high level of function throughout life. Here we studied outbred rats, which also exhibit individual differences across a spectrum of outcomes that includes both preserved and impaired spatial memory. Previous work in this model identified the CA3 subfield of the hippocampus as a region critically affected by age and integral to differing cognitive outcomes. Earlier microarray profiling revealed distinct gene expression profiles in the CA3 region, under basal conditions, for aged rats with intact memory and those with impairment. Because prominent age-related deficits within the CA3 occur during neural encoding of new information, here we used microarray analysis to gain a broad perspective of the aged CA3 transcriptome under activated conditions. Behaviorally-induced CA3 expression profiles differentiated aged rats with intact memory from those with impaired memory. In the activated profile, we observed substantial numbers of genes (greater than 1000) exhibiting increased expression in aged unimpaired rats relative to aged impaired, including many involved in synaptic plasticity and memory mechanisms. This unimpaired aged profile also over...Continue Reading

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Citations

Nov 2, 2014·Science·Ulman Lindenberger
Nov 27, 2015·Trends in Neurosciences·Stephanie L Leal, Michael A Yassa
Oct 9, 2015·PloS One·James P KesbySvetlana Semenova
Jan 21, 2017·Neurobiology of Aging·Rebecca P HabermanMichela Gallagher
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Dec 9, 2020·Archives of Physiology and Biochemistry·Yosra DallagiNarges El Golli
Sep 18, 2014·Learning & Memory·Amy M SpiegelPeter R Rapp

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Methods Mentioned

BETA
MDS
PCA
gene
chip
gene array
dissection

Software Mentioned

DAVID
SAM
HVS Image Analyzing VP -
Significance Analysis in Microarray ( SAM )
Bioconductor
gcrma
MDS
R
HVS Imaging

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