PMID: 9630168Jun 18, 1998Paper

Behaviorally conditioned effects of Cyclosporine A on the immune system of rats: specific alterations of blood leukocyte numbers and decrease of granulocyte function

Journal of Neuroimmunology
Stephan von HörstenJ Westermann

Abstract

Immunosuppression induced by Cyclosporine A (CsA) can be behaviorally conditioned. It is unknown, however, whether a taste aversion paradigm using CsA as an unconditioned stimulus (UCS) induces alterations of blood leukocyte numbers and function. Results obtained by three-colour flow cytometry and granulocyte chemiluminescence response demonstrate that in conditioned rats, absolute numbers of lymphocyte subsets, including B, CD8+ T cells and CD4+ naive and memory T cells, and granulocyte numbers and function were significantly decreased. In contrast to the conditioned response, CsA treatment alone increased lymphocyte numbers and did not affect granulocyte function. Thus, our data demonstrate that behaviorally conditioned CsA effects can be monitored in the blood. In addition, results indicate that the CNS mediates the behaviorally conditioned immunosuppression by reducing the availability and function of granulocytes and lymphocytes.

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Citations

Jun 25, 1999·Neuroscience Letters·C V BorlonganS Watanabe
Dec 4, 2003·Brain, Behavior, and Immunity·Enrique EspinosaFederico Bermúdez-Rattoni
May 18, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sabine VitsManfred Schedlowski
Nov 30, 2002·Journal of Neuroimmunology·Michael S ExtonManfred Schedlowski
Sep 2, 1998·Transplantation Proceedings·M S ExtonM Schedlowski
Sep 15, 2015·Brain, Behavior, and Immunity·Laura LueckemannManfred Schedlowski
Aug 23, 2019·Physiological Reviews·Martin HadamitzkyManfred Schedlowski
Jun 11, 1999·The American Journal of Physiology·M S ExtonM Schedlowski
Sep 27, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M S ExtonM Schedlowski

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