Behaviorally induced sensitivity to the discriminable properties of LSD.

Psychopharmacologia
I GreenbergJ B Appel

Abstract

Rats were initially trained to discriminate LSD from saline in two-lever operant chambers by reinforcing responses only on one lever following intraperitoneal injections of 80 mug/kg of LSD and only on the other lever following saline injections. Choice responding during extinction periods (no water reinforcement for either response) indicated a high level of discriminability (95% correct) following either LSD or saline. A dose-response curve for LSD, obtained by tests for lever choice after injections of 10, 20, 30, 40, 50, and 60 mug/kg, indicated that 10 mug/kg produced only 30% responding on the LSD lever. This percentage was increased (to 83%) by reinforcing responding on the LSD lever following injections of 10 mug/kg. Subsequent tests indicated that doses of 5.0 and 2.5 mug/kg produced a majority of responses on the LSD lever. Since at these low doses LSD has few measurable biochemical or behavioral effects, we hypothesized that the discriminable cue of LSD is related to direct stimulation of central serotonergic receptors.

References

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Citations

Jan 1, 1980·Psychopharmacology·J M WitkinL A Dykstra
Jan 1, 1987·Psychopharmacology·G L Kaempf, M J Kallman
Feb 12, 2008·Psychopharmacology·Torbjörn U C JärbeAlexandros Makriyannis
Aug 21, 2008·Psychopharmacology·Herbert Barry, James B Appel
Apr 1, 1978·Neuropharmacology·D M KuhnJ B Appel
Jul 1, 1976·Pharmacology, Biochemistry, and Behavior·J A Joseph, J B Appel
Sep 1, 1977·Pharmacology, Biochemistry, and Behavior·M McKenna, B T Ho
Apr 1, 1979·Pharmacology, Biochemistry, and Behavior·T U JärbeM D Swedberg
Oct 1, 1980·Pharmacology, Biochemistry, and Behavior·F J WhiteJ B Appel
Jul 1, 1986·Pharmacology, Biochemistry, and Behavior·M D Schechter
Jan 1, 1995·Pharmacology, Biochemistry, and Behavior·A TomieL L Peoples
Jan 1, 1981·Neuroscience and Biobehavioral Reviews·J C Todorov
Jan 1, 1982·Neuroscience and Biobehavioral Reviews·J B AppelA M Holohean
Feb 21, 2004·Neuropharmacology·I P StolermanL Schalkwyk
Oct 18, 2014·Behavioural Pharmacology·Robin McGovernWilliam C Griffin
Aug 3, 2011·Behavioural Pharmacology·Ian P StolermanKathleen A Grant
Jan 1, 1989·Journal of Psychopharmacology·I P Stolerman, H S Garcha

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