PMID: 401739Jan 1, 1977

Behaviour of glibenclamide on repeated administration to diabetic patients

European Journal of Clinical Pharmacology
L BalantJ Fabre

Abstract

Six maturity onset diabetic patients took glibenclamide 5 mg by mouth, every morning 10 min before a standard breakfast. Serum levels of immunoreactive glibenclamide, glucose and immunoreactive insulin were measured repeatedly on the first and 15th days of treatment. Measured glibenclamide blood levels were in close agreement with an analogue computer simulation of data obtained from healthy volunteers: there was no accumulation of drug in the blood, but there was strong evidence for the existence of a slowly equilibrating "deep" compartment. Considerable insulin release and correction of the breakfast-induced hyperglycaemia were observed immediately after administration of the drug, as well as 5 h later, at lunch time. The clinical significance of blood levels of glibenclamide, as well as the correlation of pharmacokinetics with pharmacodynamics, are discussed in the light of these results.

References

Jan 1, 1975·European Journal of Clinical Pharmacology·L BalantG Zahnd
Sep 12, 1970·Lancet·H GottesbürenG A Martini
Feb 1, 1973·The Journal of Clinical Pharmacology and New Drugs·L M FuccellaG Valzelli
Jul 1, 1963·The Biochemical Journal·C N HALES, P J RANDLE
May 1, 1963·Clinica Chimica Acta; International Journal of Clinical Chemistry·R ZENDER

Citations

Jan 1, 1993·European Journal of Clinical Pharmacology·L A JaberI R Welshman
Aug 1, 1977·Diabetologia·W HeptnerJ P Felber
Jun 1, 1990·British Journal of Clinical Pharmacology·S W CoppackA V Rodgers
Oct 1, 1995·Journal of Clinical Pharmacy and Therapeutics·T RydbergA Melander
Jan 1, 1985·The Diabetes Educator·D E Baker, R K Campbell
Nov 2, 1989·The New England Journal of Medicine·J E Gerich
Apr 17, 2003·European Journal of Clinical Pharmacology·A HolsteinE-H Egberts
Feb 1, 1993·The Annals of Pharmacotherapy·C E RaeD D Cook

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Blood Glucose
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