Behaviour of serum beta 2-microglobulin and acute phase reactant proteins in chronic lymphocytic leukaemia. A multicentre study

Acta Haematologica
B SpatiE H Cooper

Abstract

Changes in serum-beta 2-microglobulin (beta 2-m) levels were measured in 52 patients with chronic lymphocytic leukaemia during periods of observation of 5-43 months. While the majority of patients had elevated levels (> 3 mg/l), higher values tended to be associated with more advanced disease as assessed clinically. Patients with nonprogressive, predominantly Rai stage 0 and I disease had persistently normal or near normal beta 2-m levels, whereas patients with progressive, predominantly Rai stage II-IV disease, had higher levels often showing rapid changes. Sequential measurements of serum beta 2-m show patterns of change that reflect and may anticipate the clinical progression of the disease.

Citations

Oct 30, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·D M Goldberg, D Brown
Feb 25, 1983·Journal of Immunological Methods·D O'ReillyA R Sanderson
Oct 20, 2010·Nature Reviews. Clinical Oncology·Paula Cramer, Michael Hallek
Jul 10, 1999·Current Opinion in Hematology·W G Wierda, T J Kipps
Mar 28, 1981·British Medical Journal
Apr 29, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Zoltán MátraiTamás Masszi
Jul 1, 2006·Cancer Investigation·Brian L Abbott
Jan 1, 1980·Medical and Pediatric Oncology·E H Cooper, T Plesner
Dec 1, 1985·British Journal of Haematology·O A van DobbenburghJ Marrink
Jan 1, 1986·British Journal of Haematology·G BrenningA Ahre
Feb 13, 2003·British Journal of Haematology·William G WierdaMaher Albitar
Jun 15, 1983·Cancer·H HagbergB Simonsson
Jun 1, 1988·British Journal of Haematology·C S ScottB E Roberts
Sep 9, 2005·Hematological Oncology·Brian L Abbott
Oct 1, 1984·Hematological Oncology·J A Child, M R Kushwaha
Feb 1, 2003·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Cristiano A F ZerbiniMartha Skinner
Jan 1, 1982·Clinical and Laboratory Haematology·E MontserratM Elena
Jul 1, 1985·Scandinavian Journal of Haematology·O W Bjerrum, T Plesner

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