Behaviour of wetting films of sodium hyaluronate saline solutions

Journal of Colloid and Interface Science
Walkiria RibeiroBenilde Saramago


The behaviour of wetting films of sodium hyaluronate (NaHA) saline solutions, at physiological conditions, is investigated using interferometry. Concentrations in the range of dilute and semi-dilute regimes were chosen to assess the role of bulk molecular interactions on the surface forces. The transition from dilute to semi-dilute solutions is known to occur at c*=0.59 mg mL(-1). Dilute solutions form stable films whose behaviour is explained by van der Waals interactions. For semi-dilute solutions, the disjoining pressure vs film thickness isotherms show branches attributed to stepwise thinning or film stratification, which is interpreted in terms of a network as predicted by the theory of semi-dilute polyelectrolyte solutions. The distance between branches is 16 nm for the NaHA concentration of 2 mg mL(-1) and 12 nm for the concentration of 3.5 mg mL(-1), in agreement with the calculated correlation lengths of the polymeric network. Since no experimental evidence exists for the presence of a stable network in the bulk, this tendency for self-association should be the result of the liquid confinement. To our knowledge, the existence of oscillatory disjoining pressure isotherms in the presence of excess salt was never observed...Continue Reading


Dec 26, 2001·Biomacromolecules·W E KrauseR H Colby
Mar 23, 2002·Advances in Colloid and Interface Science·Vance Bergeron, P M Claesson
Mar 23, 2002·Advances in Colloid and Interface Science·B DiakovaM Kaisheva
Jun 5, 2003·Advances in Colloid and Interface Science·N V Churaev
Dec 31, 2003·Journal of Colloid and Interface Science·Rafael Correa, Benilde Saramago
Mar 23, 2005·Journal of Colloid and Interface Science·Rosa VazquezBenilde Saramago
Feb 7, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·D ExerowaTh Tadros

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