PMID: 8456448Feb 1, 1993Paper

Behavioural and electroencephalographic effects of Tityus serrulatus scorpion venom in rats

Toxicon : Official Journal of the International Society on Toxinology
M R Sandoval, Valquiria A C Dorce

Abstract

This study was designed to investigate the convulsant effects of T. serrulatus scorpion venom in rats. Pretreatment of rats with venom increased the minimum convulsant dose of picrotoxin, impaired convulsion generalization and displaced to the left the dose-response curve for picrotoxin. It also decreased the intensity but prolonged the duration of seizures caused by pentylenetetrazol injection. Microinjection of the venom into the dorsal hippocampus induced behavioural alterations and epileptiform waves in the EEG. Venom also altered the threshold for, and intensity of, convulsions induced in different experimental models of epilepsy. Different fractions of the venom may be responsible for these different effects. Therefore, purification of venom toxins is necessary for the complete understanding of the present results.

References

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Citations

Dec 1, 1994·Toxicon : Official Journal of the International Society on Toxinology·V A Dorce, M R Sandoval
Mar 12, 2003·Toxicology and Applied Pharmacology·Michel B S MesquitaMárcio F D Moraes
Nov 2, 2001·Toxicon : Official Journal of the International Society on Toxinology·Geane Antiques LourençoValquiria A Coronado Dorce
Feb 14, 2014·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Ana Leticia C DorceAna Leonor A Nencioni
Apr 28, 2009·Brain Research Bulletin·Roberta LuongoMaria Regina Lopes Sandoval
Feb 27, 2007·Toxicology and Applied Pharmacology·Zhi-Fang ChaiYong-Hua Ji
Feb 8, 2018·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Ana Leonor Abrahão NencioniValquiria Abrão Coronado Dorce
Aug 12, 2009·Neuroscience Letters·Ana Leonor A NencioniValquiria A C Dorce

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