Behavioural and neurobiological consequences of macrophage migration inhibitory factor gene deletion in mice

Journal of Neuroinflammation
Cecilie Bay-RichterLena Brundin

Abstract

Evidence from clinical studies and animal models show that inflammation can lead to the development of depression. Macrophage migration inhibitory factor (MIF) is an important multifunctional cytokine that is synthesized by several cell types in the brain. MIF can increase production of other cytokines, activates cyclooxygenase (COX)-2 and can counter-regulate anti-inflammatory effects of glucocorticoids. Increased plasma levels of MIF are associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation and depressive symptoms in patients. In contrast, MIF knockout (KO) mice have been found to exhibit increased depressive-like behaviour. The exact role for MIF in depression is therefore still controversial. To further understand the role of MIF in depression, we studied depressive-like behaviour in congenic male and female MIF KO mice and wild-type (WT) littermates and the associated neurobiological mechanisms underlying the behavioural outcome. MIF KO and WT mice were tested for spontaneous locomotor activity in the open-field test, anhedonia-like behaviour in the sucrose preference test (SPT), as well as behavioural despair in the forced swim test (FST) and tail suspension test (TST). Brain and serum levels of cytokine...Continue Reading

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Citations

Nov 5, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Li-Rong LinTian-Ci Yang
Jul 6, 2017·Experimental Neurology·Marcel F Leyton-JaimesAdrian Israelson
Mar 24, 2020·Acta Pharmacologica Sinica·Wen-Kai BiZhao He
Mar 17, 2020·Biochemical and Biophysical Research Communications·Wen-Kai BiZhao He
Aug 7, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Xi ChenDonghong Cui
Aug 15, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Gabriel A AquinoSilvânia M M Vasconcelos

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SMART

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