Behavioural and pharmacological investigations of 5-HT hypophagia and hyperdipsia

Pharmacology, Biochemistry, and Behavior
A M MontgomeryM J Burton

Abstract

Treatment with 5-hydroxytryptamine (5-HT) reliably induced hypophagia in non-deprived rats and in rats tested following a period of food-deprivation, regardless of the presence or absence of water during testing. The hyperdipsic effect of 5-HT, however, was sensitive to changes in the length of food-deprivation, suggesting a possible interaction between 5-HT hyperdipsia and prandial drinking. Both 5-HT hypophagia and hyperdipsia were attenuated by methysergide pretreatment, thus confirming the involvement of peripheral post-synaptic 5-HT receptors in both effects. Pretreatment with propranolol blocked 5-HT hyperdipsia, but did not alter 5-HT hypophagia, thus suggesting that 5-HT hypophagia and hyperdipsia are mediated by different mechanisms at some point subsequent to the stimulation of peripheral 5-HT receptors. These results are consistent with other evidence that 5-HT hyperdipsia is mediated by stimulation of the renin-angiotensin system. It is tentatively suggested that 5-HT hypophagia could result from 5-HT-induced inhibition of cephalic phase insulin secretion.

References

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Citations

Jan 1, 1986·Psychopharmacology·A M Montgomery, M J Burton
Nov 1, 1986·Pharmacology, Biochemistry, and Behavior·P J Fletcher
Sep 1, 1988·Pharmacology, Biochemistry, and Behavior·R B Kanarek, H Dushkin
Apr 1, 1995·Pharmacology, Biochemistry, and Behavior·J FrancisS J Cooper
Mar 1, 1994·Pharmacology, Biochemistry, and Behavior·S J Cooper, D J Barber
Jan 1, 1996·Behavioural Brain Research·K J Simansky
Jan 1, 1997·Brain Research Bulletin·S M SteffensJ Marino-Neto
May 10, 2007·Canadian Journal of Physiology and Pharmacology·Silvana Soriano FrassettoAnapaula Sommer Vinagre
Jul 22, 2009·Journal of Pediatric Endocrinology & Metabolism : JPEM·Pat MahachoklertwattanaArporn Sriphrapradang

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