PMID: 1203622Nov 1, 1975Paper

Behavioural changes induced in conscious mice by intracerebroventricular injection of catecholamines, acetylcholine and 5-hydroxytryptamine

British Journal of Pharmacology
Z S Herman

Abstract

1 A simple method of injecting soluble substances into the lateral ventricle of the brain of the conscious mouse is described. 2 The effect of various doses of noradrenaline, dopamine, acetylcholine, 5-hydroxytryptamine given into the right lateral brain ventricle were tested on locomotor and exploratory activities of mice. 3 Noradrenaline in a dose of 0.1 mug increased locomotor activity. This effect was prevented by phenoxybensamine but not by propranolol. 4 Higher doses of noradrenaline (1 or 10 mug) decreased locomotor and exploratory activities. Propranolol but not phenoxybenzamine abolished these effects. 5 Dopamine (0.1 or 1 mug) increased locomotor activity. The higher doses also induced tremor. 6 The highese dose of dopamine tested (10 mug) elicited stereotypical behaviour. 7 All the behavioural phenomena induced by 0.1 mug and 10 mug of dopamine were blocked by pimozide. 8 Acetylcholine (1 and 10 mug) and 5-hydroxytryptamine (1 mug) inhibited locomotor and exploratory activity. 9 The effects of 1 and 10 mug of acetylcholine were abolished by atropine (5 mg/kg i.p. Methysergide (5 mg/kg i.p.) had no influence on the effects of 5-hydroxytryptamine (1 mug).

References

Jan 1, 1972·Psychopharmacologia·Z S HermanR Szkilnik
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Jan 1, 1970·Psychopharmacologia·Z S Herman
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Citations

Jun 28, 1979·Psychopharmacology·R BrusJ Zabawska
Oct 1, 1991·Neurochemical Research·Y WatanabeA Mori
Mar 15, 1978·European Journal of Pharmacology·L BeaniF Tamberi
Dec 1, 1977·Pharmacology, Biochemistry, and Behavior·B Holmgren, R Urba-Holmgren
Apr 1, 1980·Pharmacology, Biochemistry, and Behavior·J B ThurmondJ W Brown
Jan 1, 1983·Progress in Neurobiology·R H FishmanH L Klawans
Aug 15, 2001·European Journal of Pharmacology·A I CzłonkowskaA Płaźnik
Jun 14, 2002·Pharmacology, Biochemistry, and Behavior·Piotr MaciejakAdam Plaznik
Sep 27, 2008·Pharmacology, Biochemistry, and Behavior·Takayuki HayashiYoriko Kawakami
Aug 11, 2004·Pharmacology, Biochemistry, and Behavior·P MaciejakA Płaźnik
Jan 1, 1983·Annals of the New York Academy of Sciences·Z S HermanE Nawrocka
Dec 3, 2016·Pharmacological Reports : PR·Anna Cioczek-CzuczwarJolanta Parada-Turska
Jan 1, 1981·The Journal of Pharmacy and Pharmacology·S J CzuczwarZ Kleinrok

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